Effects of nicotine self-administration on incentive salience in male Sprague Dawley rats

Paula F. Overby, Carter W. Daniels, Armani Del Franco, Julianna Goenaga, Gregory L. Powell, Cassandra Gipson-Reichardt, Federico Sanabria

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Rationale: Prolonged use of nicotine appears to enhance incentive salience, a motivational-cognitive process that transforms an otherwise neutral stimulus into a “wanted” stimulus. It has been suggested that nicotinic enhancement of incentive salience contributes to the potential of relapse in individuals with tobacco addiction. However, there are two main limitations of prior research that caution this claim: (a) the use of passive experimentally delivered nicotine and (b) the use of sign-tracking as an index of incentive salience, without acknowledging the competing nature of goal- and sign-tracking responses. Objectives: To determine whether nicotinic enhancement of incentive salience attributed to non-nicotinic stimuli occurs when rats self-administer nicotine, and whether it is facilitated by a prior history of nicotine self-administration. Methods: Twenty-three male rats were trained daily, for 24 days, on a nicotine self-administration (SA) paradigm in the morning, and on a four-conditioned-stimuli Pavlovian conditioned approach (4-CS PCA) task in the afternoon. Self-administration was followed by extinction and cue reinstatement. A subcutaneous nicotine challenge was performed during the last 7 days of the study. Results: Nicotine self-administration selectively enhanced sign-tracking in the 4-CS PCA. Upon extinction, sign-tracking quickly declined to control levels. Experimenter-administered nicotine enhanced sign-tracking similarly regardless of nicotine history. Conclusions: The results suggest that nicotinic enhancement of incentive salience is transient, and a previous history of nicotine use does not cause further sensitization. Taken together, these results suggest that nicotine enhances incentive salience, particularly—and perhaps exclusively—while onboard.

Original languageEnglish (US)
Pages (from-to)1-10
Number of pages10
JournalPsychopharmacology
DOIs
StateAccepted/In press - Jan 26 2018

Fingerprint

Self Administration
Nicotine
Sprague Dawley Rats
Motivation
Passive Cutaneous Anaphylaxis
Tobacco
Cues
History

Keywords

  • Goal-tracking
  • Incentive salience
  • Nicotine
  • Pavlovian conditioned approach
  • Rats
  • Self-administration
  • Sign-tracking

ASJC Scopus subject areas

  • Pharmacology

Cite this

Effects of nicotine self-administration on incentive salience in male Sprague Dawley rats. / Overby, Paula F.; Daniels, Carter W.; Del Franco, Armani; Goenaga, Julianna; Powell, Gregory L.; Gipson-Reichardt, Cassandra; Sanabria, Federico.

In: Psychopharmacology, 26.01.2018, p. 1-10.

Research output: Contribution to journalArticle

Overby, Paula F. ; Daniels, Carter W. ; Del Franco, Armani ; Goenaga, Julianna ; Powell, Gregory L. ; Gipson-Reichardt, Cassandra ; Sanabria, Federico. / Effects of nicotine self-administration on incentive salience in male Sprague Dawley rats. In: Psychopharmacology. 2018 ; pp. 1-10.
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abstract = "Rationale: Prolonged use of nicotine appears to enhance incentive salience, a motivational-cognitive process that transforms an otherwise neutral stimulus into a “wanted” stimulus. It has been suggested that nicotinic enhancement of incentive salience contributes to the potential of relapse in individuals with tobacco addiction. However, there are two main limitations of prior research that caution this claim: (a) the use of passive experimentally delivered nicotine and (b) the use of sign-tracking as an index of incentive salience, without acknowledging the competing nature of goal- and sign-tracking responses. Objectives: To determine whether nicotinic enhancement of incentive salience attributed to non-nicotinic stimuli occurs when rats self-administer nicotine, and whether it is facilitated by a prior history of nicotine self-administration. Methods: Twenty-three male rats were trained daily, for 24 days, on a nicotine self-administration (SA) paradigm in the morning, and on a four-conditioned-stimuli Pavlovian conditioned approach (4-CS PCA) task in the afternoon. Self-administration was followed by extinction and cue reinstatement. A subcutaneous nicotine challenge was performed during the last 7 days of the study. Results: Nicotine self-administration selectively enhanced sign-tracking in the 4-CS PCA. Upon extinction, sign-tracking quickly declined to control levels. Experimenter-administered nicotine enhanced sign-tracking similarly regardless of nicotine history. Conclusions: The results suggest that nicotinic enhancement of incentive salience is transient, and a previous history of nicotine use does not cause further sensitization. Taken together, these results suggest that nicotine enhances incentive salience, particularly—and perhaps exclusively—while onboard.",
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