Effects of nicotine dose and administration method on withdrawal symptoms and side effects during short-term smoking abstinence

Scott Leischow, Suzanne N. Valente, Anabel L. Hill, Pamela S. Otte, Mikel Aickin, Timothy Holden, Evan Kligman, Gretchen Cook

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

The effects of using several different nicotine replacement treatments on self-reported withdrawal symptoms and side effects during 2-day periods of smoking cessation, with 5 days of ad lib smoking between cessation days, were evaluated. Participants (N = 18) experienced the following conditions: nicotine gum, 24-hr patch, 16-hr patch, 24-hr patch plus gum, double 24-hr patch, and no nicotine replacement. The present study found morning urge to smoke was greater during the 16-hr than during the 24-hr patch condition. Double-patch use resulted in significantly greater insomnia than the smoking baseline and 16-hr patch conditions. The no medication and gum alone conditions resulted in similar withdrawal symptoms, and both tended to result in greater reported withdrawal symptoms than the smoking baseline condition. There were no significant withdrawal symptom differences between the 24-hr, patch-gum, and double-patch conditions. The 24-hr and double-patch conditions were preferred by two thirds of the participants (6 each).

Original languageEnglish (US)
Pages (from-to)54-64
Number of pages11
JournalExperimental and clinical psychopharmacology
Volume5
Issue number1
DOIs
StatePublished - Feb 1 1997

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)

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