35 Citations (Scopus)

Abstract

We hypothesized that high-intensity interval training (HIIT) would be more effective than moderate-intensity continuous training (MICT) at improving endothelial function and maximum oxygen uptake (V? O2 max) in obese adults. Eighteen participants [35.1 8.1 (SD) yr; body mass index 36.0 5.0 kg/m2] were randomized to 8 wk (3 sessions/wk) of either HIIT [10 1 min, 90-95% maximum heart rate (HRmax), 1-min active recovery] or MICT (30 min, 70-75% HRmax). Brachial artery flow-mediated dilation (FMD) increased after HIIT (5.13 2.80% vs. 8.98 2.86%, P<0.02) but not after MICT (5.23 2.82% vs. 3.05 2.76%, P<0.16). Resting artery diameter increased after MICT (3.68 0.58 mm vs. 3.86 0.58 mm, P<0.02) but not after HIIT (4.04 0.70 mm vs. 4.09 0.70 mm; P<0.63). There was a significant (P<0.02) group time interaction in low flowmediated constriction (L-FMC) between MICT (0.63 2.00% vs. 2.79 3.20%; P<0.03) and HIIT (1.04 4.09% vs. 1.74 3.46%; P<0.29). V ? O2 max increased (P-0.01) similarly after HIIT (2.19 0.65 l/min vs. 2.64 0.88 l/min) and MICT (2.24 0.48 l/min vs. 2.55 0.61 l/min). Biomarkers of cardiovascular risk and endothelial function were unchanged. HIIT and MICT produced different vascular adaptations in obese adults, with HIIT improving FMD and MICT increasing resting artery diameter and enhancing L-FMC. HIIT required 27.5% less total exercise time and 25% less energy expenditure than MICT.

Original languageEnglish (US)
Pages (from-to)279-288
Number of pages10
JournalJournal of Applied Physiology
Volume121
Issue number1
DOIs
StatePublished - Jul 1 2016

Fingerprint

Constriction
Dilatation
Arteries
High-Intensity Interval Training
Brachial Artery
Energy Metabolism
Blood Vessels
Body Mass Index
Biomarkers
Heart Rate
Exercise
Oxygen

Keywords

  • Cardiovascular
  • Exercise
  • Fitness
  • Flow-mediated dilation
  • Obesity

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults. / Sawyer, Brandon J.; Tucker, Wesley J.; Bhammar, Dharini M.; Ryder, Justin R.; Sweazea, Karen; Gaesser, Glenn.

In: Journal of Applied Physiology, Vol. 121, No. 1, 01.07.2016, p. 279-288.

Research output: Contribution to journalArticle

@article{fa7a328db6a04e718f46c96a7294f96e,
title = "Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults",
abstract = "We hypothesized that high-intensity interval training (HIIT) would be more effective than moderate-intensity continuous training (MICT) at improving endothelial function and maximum oxygen uptake (V? O2 max) in obese adults. Eighteen participants [35.1 8.1 (SD) yr; body mass index 36.0 5.0 kg/m2] were randomized to 8 wk (3 sessions/wk) of either HIIT [10 1 min, 90-95{\%} maximum heart rate (HRmax), 1-min active recovery] or MICT (30 min, 70-75{\%} HRmax). Brachial artery flow-mediated dilation (FMD) increased after HIIT (5.13 2.80{\%} vs. 8.98 2.86{\%}, P<0.02) but not after MICT (5.23 2.82{\%} vs. 3.05 2.76{\%}, P<0.16). Resting artery diameter increased after MICT (3.68 0.58 mm vs. 3.86 0.58 mm, P<0.02) but not after HIIT (4.04 0.70 mm vs. 4.09 0.70 mm; P<0.63). There was a significant (P<0.02) group time interaction in low flowmediated constriction (L-FMC) between MICT (0.63 2.00{\%} vs. 2.79 3.20{\%}; P<0.03) and HIIT (1.04 4.09{\%} vs. 1.74 3.46{\%}; P<0.29). V ? O2 max increased (P-0.01) similarly after HIIT (2.19 0.65 l/min vs. 2.64 0.88 l/min) and MICT (2.24 0.48 l/min vs. 2.55 0.61 l/min). Biomarkers of cardiovascular risk and endothelial function were unchanged. HIIT and MICT produced different vascular adaptations in obese adults, with HIIT improving FMD and MICT increasing resting artery diameter and enhancing L-FMC. HIIT required 27.5{\%} less total exercise time and 25{\%} less energy expenditure than MICT.",
keywords = "Cardiovascular, Exercise, Fitness, Flow-mediated dilation, Obesity",
author = "Sawyer, {Brandon J.} and Tucker, {Wesley J.} and Bhammar, {Dharini M.} and Ryder, {Justin R.} and Karen Sweazea and Glenn Gaesser",
year = "2016",
month = "7",
day = "1",
doi = "10.1152/japplphysiol.00024.2016",
language = "English (US)",
volume = "121",
pages = "279--288",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "1",

}

TY - JOUR

T1 - Effects of high-intensity interval training and moderate-intensity continuous training on endothelial function and cardiometabolic risk markers in obese adults

AU - Sawyer, Brandon J.

AU - Tucker, Wesley J.

AU - Bhammar, Dharini M.

AU - Ryder, Justin R.

AU - Sweazea, Karen

AU - Gaesser, Glenn

PY - 2016/7/1

Y1 - 2016/7/1

N2 - We hypothesized that high-intensity interval training (HIIT) would be more effective than moderate-intensity continuous training (MICT) at improving endothelial function and maximum oxygen uptake (V? O2 max) in obese adults. Eighteen participants [35.1 8.1 (SD) yr; body mass index 36.0 5.0 kg/m2] were randomized to 8 wk (3 sessions/wk) of either HIIT [10 1 min, 90-95% maximum heart rate (HRmax), 1-min active recovery] or MICT (30 min, 70-75% HRmax). Brachial artery flow-mediated dilation (FMD) increased after HIIT (5.13 2.80% vs. 8.98 2.86%, P<0.02) but not after MICT (5.23 2.82% vs. 3.05 2.76%, P<0.16). Resting artery diameter increased after MICT (3.68 0.58 mm vs. 3.86 0.58 mm, P<0.02) but not after HIIT (4.04 0.70 mm vs. 4.09 0.70 mm; P<0.63). There was a significant (P<0.02) group time interaction in low flowmediated constriction (L-FMC) between MICT (0.63 2.00% vs. 2.79 3.20%; P<0.03) and HIIT (1.04 4.09% vs. 1.74 3.46%; P<0.29). V ? O2 max increased (P-0.01) similarly after HIIT (2.19 0.65 l/min vs. 2.64 0.88 l/min) and MICT (2.24 0.48 l/min vs. 2.55 0.61 l/min). Biomarkers of cardiovascular risk and endothelial function were unchanged. HIIT and MICT produced different vascular adaptations in obese adults, with HIIT improving FMD and MICT increasing resting artery diameter and enhancing L-FMC. HIIT required 27.5% less total exercise time and 25% less energy expenditure than MICT.

AB - We hypothesized that high-intensity interval training (HIIT) would be more effective than moderate-intensity continuous training (MICT) at improving endothelial function and maximum oxygen uptake (V? O2 max) in obese adults. Eighteen participants [35.1 8.1 (SD) yr; body mass index 36.0 5.0 kg/m2] were randomized to 8 wk (3 sessions/wk) of either HIIT [10 1 min, 90-95% maximum heart rate (HRmax), 1-min active recovery] or MICT (30 min, 70-75% HRmax). Brachial artery flow-mediated dilation (FMD) increased after HIIT (5.13 2.80% vs. 8.98 2.86%, P<0.02) but not after MICT (5.23 2.82% vs. 3.05 2.76%, P<0.16). Resting artery diameter increased after MICT (3.68 0.58 mm vs. 3.86 0.58 mm, P<0.02) but not after HIIT (4.04 0.70 mm vs. 4.09 0.70 mm; P<0.63). There was a significant (P<0.02) group time interaction in low flowmediated constriction (L-FMC) between MICT (0.63 2.00% vs. 2.79 3.20%; P<0.03) and HIIT (1.04 4.09% vs. 1.74 3.46%; P<0.29). V ? O2 max increased (P-0.01) similarly after HIIT (2.19 0.65 l/min vs. 2.64 0.88 l/min) and MICT (2.24 0.48 l/min vs. 2.55 0.61 l/min). Biomarkers of cardiovascular risk and endothelial function were unchanged. HIIT and MICT produced different vascular adaptations in obese adults, with HIIT improving FMD and MICT increasing resting artery diameter and enhancing L-FMC. HIIT required 27.5% less total exercise time and 25% less energy expenditure than MICT.

KW - Cardiovascular

KW - Exercise

KW - Fitness

KW - Flow-mediated dilation

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=84983775704&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84983775704&partnerID=8YFLogxK

U2 - 10.1152/japplphysiol.00024.2016

DO - 10.1152/japplphysiol.00024.2016

M3 - Article

C2 - 27255523

AN - SCOPUS:84983775704

VL - 121

SP - 279

EP - 288

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 1

ER -