Effects of experimental sleep restriction on caloric intake and activity energy expenditure

Andrew D. Calvin, Rickey E. Carter, Taro Adachi, Paula G. MacEdo, Felipe N. Albuquerque, Christelle Van Der Walt, Jan Bukartyk, Diane E. Davison, James A. Levine, Virend K. Somers

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insuffi- cient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Results: Caloric intake in the sleep-restricted group increased by + 559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by - 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of + 677 kcal/d (95% CI, 148-1,206 kcal/d; P = .014). Sleep restriction was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21). Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.

Original languageEnglish (US)
Pages (from-to)79-86
Number of pages8
JournalChest
Volume144
Issue number1
DOIs
StatePublished - Jul 2013
Externally publishedYes

Fingerprint

Energy Intake
Energy Metabolism
Sleep
Ghrelin
Leptin
Obesity
Appetite
Weight Gain
Epidemiologic Studies
Hormones
Control Groups

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Calvin, A. D., Carter, R. E., Adachi, T., MacEdo, P. G., Albuquerque, F. N., Van Der Walt, C., ... Somers, V. K. (2013). Effects of experimental sleep restriction on caloric intake and activity energy expenditure. Chest, 144(1), 79-86. https://doi.org/10.1378/chest.12-2829

Effects of experimental sleep restriction on caloric intake and activity energy expenditure. / Calvin, Andrew D.; Carter, Rickey E.; Adachi, Taro; MacEdo, Paula G.; Albuquerque, Felipe N.; Van Der Walt, Christelle; Bukartyk, Jan; Davison, Diane E.; Levine, James A.; Somers, Virend K.

In: Chest, Vol. 144, No. 1, 07.2013, p. 79-86.

Research output: Contribution to journalArticle

Calvin, AD, Carter, RE, Adachi, T, MacEdo, PG, Albuquerque, FN, Van Der Walt, C, Bukartyk, J, Davison, DE, Levine, JA & Somers, VK 2013, 'Effects of experimental sleep restriction on caloric intake and activity energy expenditure', Chest, vol. 144, no. 1, pp. 79-86. https://doi.org/10.1378/chest.12-2829
Calvin AD, Carter RE, Adachi T, MacEdo PG, Albuquerque FN, Van Der Walt C et al. Effects of experimental sleep restriction on caloric intake and activity energy expenditure. Chest. 2013 Jul;144(1):79-86. https://doi.org/10.1378/chest.12-2829
Calvin, Andrew D. ; Carter, Rickey E. ; Adachi, Taro ; MacEdo, Paula G. ; Albuquerque, Felipe N. ; Van Der Walt, Christelle ; Bukartyk, Jan ; Davison, Diane E. ; Levine, James A. ; Somers, Virend K. / Effects of experimental sleep restriction on caloric intake and activity energy expenditure. In: Chest. 2013 ; Vol. 144, No. 1. pp. 79-86.
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abstract = "Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insuffi- cient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Results: Caloric intake in the sleep-restricted group increased by + 559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by - 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of + 677 kcal/d (95{\%} CI, 148-1,206 kcal/d; P = .014). Sleep restriction was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21). Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.",
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AU - Adachi, Taro

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AU - Albuquerque, Felipe N.

AU - Van Der Walt, Christelle

AU - Bukartyk, Jan

AU - Davison, Diane E.

AU - Levine, James A.

AU - Somers, Virend K.

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N2 - Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insuffi- cient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Results: Caloric intake in the sleep-restricted group increased by + 559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by - 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of + 677 kcal/d (95% CI, 148-1,206 kcal/d; P = .014). Sleep restriction was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21). Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.

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