TY - JOUR
T1 - Effects of experimental sleep restriction on caloric intake and activity energy expenditure
AU - Calvin, Andrew D.
AU - Carter, Rickey E.
AU - Adachi, Taro
AU - MacEdo, Paula G.
AU - Albuquerque, Felipe N.
AU - Van Der Walt, Christelle
AU - Bukartyk, Jan
AU - Davison, Diane E.
AU - Levine, James A.
AU - Somers, Virend K.
N1 - Funding Information:
Financial/nonfinancial disclosures: The authors have reported to CHEST the following conflicts of interest: Dr Somers is supported by NIH [ Grant HL65176, UL1 RR024150, HL96071, HL114024, and HL114676 ] and the Mayo Foundation. Dr Somers has served as a consultant for ResMed; Respicardia; NeuPro; Apnex Medical, Inc; Medtronic; Deshum Medical; and Sova Pharmaceuticals. He has served as a PI or coinvestigator on grants from Philips Respironics Foundation and the NIH and works with Mayo Health Solutions on intellectual property related to sleep and to obesity. Drs Calvin, Carter, Adachi, Macedo, Albuquerque, and Levine, Mss van der Walt and Davison, and Mr Bukartyk have reported that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.
Funding Information:
Funding/Support: This work was supported by the Mayo Foundation and the Mayo Clinic Clinician-Investigator Training Program (to Dr Calvin); the National Heart Lung and Blood Institute [ Grant 096071 ]; the National Institutes of Health (NIH) [ Grant R201 HL096071 and R01 HL114024 ]; and the National Center for Research Resources (NCRR) [ Grant 1ULI RR024150 ], a component of the NIH and the NIH Roadmap for Medical Research. These studies were also supported by grants from the Czech Ministry of Health [ NS 10098-4/2008 ] and by European Regional Development Fund - Project FNUSA-ICRC [ CZ.1.05/1.1.00/02.0123 ].
PY - 2013/7
Y1 - 2013/7
N2 - Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insuffi- cient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Results: Caloric intake in the sleep-restricted group increased by + 559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by - 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of + 677 kcal/d (95% CI, 148-1,206 kcal/d; P = .014). Sleep restriction was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21). Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.
AB - Background: Epidemiologic studies link short sleep duration to obesity and weight gain. Insuffi- cient sleep appears to alter circulating levels of the hormones leptin and ghrelin, which may promote appetite, although the effects of sleep restriction on caloric intake and energy expenditure are unclear. We sought to determine the effect of 8 days/8 nights of sleep restriction on caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Methods: We conducted a randomized study of usual sleep vs a sleep restriction of two-thirds of normal sleep time for 8 days/8 nights in a hospital-based clinical research unit. The main outcomes were caloric intake, activity energy expenditure, and circulating levels of leptin and ghrelin. Results: Caloric intake in the sleep-restricted group increased by + 559 kcal/d (SD, 706 kcal/d, P = .006) and decreased in the control group by - 118 kcal/d (SD, 386 kcal/d, P = .51) for a net change of + 677 kcal/d (95% CI, 148-1,206 kcal/d; P = .014). Sleep restriction was not associated with changes in activity energy expenditure (P = .62). No change was seen in levels of leptin (P = .27) or ghrelin (P = .21). Conclusions: Sleep restriction was associated with an increase in caloric consumption with no change in activity energy expenditure or leptin and ghrelin concentrations. Increased caloric intake without any accompanying increase in energy expenditure may contribute to obesity in people who are exposed to long-term sleep restriction.
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U2 - 10.1378/chest.12-2829
DO - 10.1378/chest.12-2829
M3 - Article
C2 - 23392199
AN - SCOPUS:84880067896
SN - 0012-3692
VL - 144
SP - 79
EP - 86
JO - Chest
JF - Chest
IS - 1
ER -