TY - GEN
T1 - Effects of deep brain stimulation on dynamic posture shifts in Parkinson's disease
AU - Krishnamurthi, Narayanan
AU - Mulligan, Stefani
AU - Mahant, Padma
AU - Samanta, Johan
AU - Abbas, James
PY - 2009
Y1 - 2009
N2 - Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is now widely used to alleviate symptoms of Parkinson's disease (PD). The long-term goal is to develop a quantitative tool to facilitate selection of DBS settings in the clinic since the typical parameter selection process may not adequately consider the effects of DBS on posture control. The aim of this study was to characterize the effects of changing the stimulation amplitude of DBS on posture control in PD. A dynamic posture shift paradigm involving target acquisition was used to assess posture control in 4 PD STN-DBS subjects. Each subject was tested at 4 stimulation amplitude settings: Clinically-determined (CD) settings, moderate (approx. 70% CD), low (approx. 30% CD), and off (no stimulation). Movements of the center of pressure and the position of the pelvis were monitored and several quantitative indices were calculated. The most substantial change was reductions in the peak velocity and the average movement velocity during the initial and mid phases of movement towards the target posture. These results may be explained in terms of increased akinesia and bradykinesia in the altered stimulation conditions. Thus, the dynamic posture shift paradigm can reveal changes in posture control capabilities, as evidenced by changes in movement velocity, due to alterations in DBS stimulation settings.
AB - Deep Brain Stimulation (DBS) of the subthalamic nucleus (STN) is now widely used to alleviate symptoms of Parkinson's disease (PD). The long-term goal is to develop a quantitative tool to facilitate selection of DBS settings in the clinic since the typical parameter selection process may not adequately consider the effects of DBS on posture control. The aim of this study was to characterize the effects of changing the stimulation amplitude of DBS on posture control in PD. A dynamic posture shift paradigm involving target acquisition was used to assess posture control in 4 PD STN-DBS subjects. Each subject was tested at 4 stimulation amplitude settings: Clinically-determined (CD) settings, moderate (approx. 70% CD), low (approx. 30% CD), and off (no stimulation). Movements of the center of pressure and the position of the pelvis were monitored and several quantitative indices were calculated. The most substantial change was reductions in the peak velocity and the average movement velocity during the initial and mid phases of movement towards the target posture. These results may be explained in terms of increased akinesia and bradykinesia in the altered stimulation conditions. Thus, the dynamic posture shift paradigm can reveal changes in posture control capabilities, as evidenced by changes in movement velocity, due to alterations in DBS stimulation settings.
UR - http://www.scopus.com/inward/record.url?scp=67650664267&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=67650664267&partnerID=8YFLogxK
U2 - 10.1109/ICCME.2009.4906651
DO - 10.1109/ICCME.2009.4906651
M3 - Conference contribution
AN - SCOPUS:67650664267
SN - 9781424433162
T3 - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
BT - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
T2 - 2009 ICME International Conference on Complex Medical Engineering, CME 2009
Y2 - 9 April 2009 through 11 April 2009
ER -