Effects of bilayer surface charge density on molecular adsorption and transport across liposome bilayers

Yan Liu, Elsa C Y Yan, Kenneth B. Eisenthal

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

Second harmonic generation (SHG) was used to study both the adsorption of malachite green (MG), a positively charged organic dye, onto liposomes of different lipid compositions, and the transport kinetics of MG across the liposome bilayer in real time. We found that the dye adsorption increased linearly with the fraction of negatively charged lipids in the bilayer. Similarly, the transport rate constant for crossing the bilayer increased linearly with the fraction of charged lipid in the bilayer.

Original languageEnglish (US)
Pages (from-to)1004-1012
Number of pages9
JournalBiophysical Journal
Volume80
Issue number2
StatePublished - 2001
Externally publishedYes

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Lipid Bilayers
Liposomes
Adsorption
Coloring Agents
Lipids
malachite green

ASJC Scopus subject areas

  • Biophysics

Cite this

Effects of bilayer surface charge density on molecular adsorption and transport across liposome bilayers. / Liu, Yan; Yan, Elsa C Y; Eisenthal, Kenneth B.

In: Biophysical Journal, Vol. 80, No. 2, 2001, p. 1004-1012.

Research output: Contribution to journalArticle

Liu, Yan ; Yan, Elsa C Y ; Eisenthal, Kenneth B. / Effects of bilayer surface charge density on molecular adsorption and transport across liposome bilayers. In: Biophysical Journal. 2001 ; Vol. 80, No. 2. pp. 1004-1012.
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