Effects of an 8-week high-protein or high-carbohydrate diet in adults with hyperinsulinemia

Rima E. Kleiner, Andrea M. Hutchins, Carol Johnston, Pamela Swan

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Context: Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with • 5% loss in body weight. Objective: To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR. Design: Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks. Setting: All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption. Patients: Twenty overweight, healthy participants with elevated fasting serum insulin (≥ 15 μU/L) were recruited. Interventions: Both diets were low-fat (27% kcal from fat; < 7% saturated, ≤ 10% monounsaturated, and ≤ 10% polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); resting metabolic rate. Main Outcome Measures: Body composition, metabolic indices, fasting plasma glucose, and insulin. Results: No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5%; HCLF: -0.4%) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively). Conclusion: Both diets promoted ≥ 5% loss in body weight and significantly reduced percent body fat.

Original languageEnglish (US)
JournalMedGenMed Medscape General Medicine
Volume8
Issue number4
StatePublished - 2006

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Hyperinsulinism
Fats
Carbohydrates
Diet
Body Weight
Insulin Resistance
Fat-Restricted Diet
Proteins
Body Composition
Meals
Adipose Tissue
Fasting
Outcome Assessment (Health Care)
Insulin
Reducing Diet
Basal Metabolism
Lunch
Healthy Volunteers
Glucose
Incidence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Effects of an 8-week high-protein or high-carbohydrate diet in adults with hyperinsulinemia. / Kleiner, Rima E.; Hutchins, Andrea M.; Johnston, Carol; Swan, Pamela.

In: MedGenMed Medscape General Medicine, Vol. 8, No. 4, 2006.

Research output: Contribution to journalArticle

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abstract = "Context: Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with • 5{\%} loss in body weight. Objective: To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR. Design: Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks. Setting: All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption. Patients: Twenty overweight, healthy participants with elevated fasting serum insulin (≥ 15 μU/L) were recruited. Interventions: Both diets were low-fat (27{\%} kcal from fat; < 7{\%} saturated, ≤ 10{\%} monounsaturated, and ≤ 10{\%} polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); resting metabolic rate. Main Outcome Measures: Body composition, metabolic indices, fasting plasma glucose, and insulin. Results: No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5{\%}; HCLF: -0.4{\%}) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively). Conclusion: Both diets promoted ≥ 5{\%} loss in body weight and significantly reduced percent body fat.",
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N2 - Context: Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with • 5% loss in body weight. Objective: To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR. Design: Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks. Setting: All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption. Patients: Twenty overweight, healthy participants with elevated fasting serum insulin (≥ 15 μU/L) were recruited. Interventions: Both diets were low-fat (27% kcal from fat; < 7% saturated, ≤ 10% monounsaturated, and ≤ 10% polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); resting metabolic rate. Main Outcome Measures: Body composition, metabolic indices, fasting plasma glucose, and insulin. Results: No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5%; HCLF: -0.4%) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively). Conclusion: Both diets promoted ≥ 5% loss in body weight and significantly reduced percent body fat.

AB - Context: Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with • 5% loss in body weight. Objective: To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR. Design: Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks. Setting: All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption. Patients: Twenty overweight, healthy participants with elevated fasting serum insulin (≥ 15 μU/L) were recruited. Interventions: Both diets were low-fat (27% kcal from fat; < 7% saturated, ≤ 10% monounsaturated, and ≤ 10% polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); resting metabolic rate. Main Outcome Measures: Body composition, metabolic indices, fasting plasma glucose, and insulin. Results: No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5%; HCLF: -0.4%) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively). Conclusion: Both diets promoted ≥ 5% loss in body weight and significantly reduced percent body fat.

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