Effects of amphetamine and 6-hydroxydopamine lesions on reserpine-induced oral dyskinesia

Janet Neisewander, Edward Castañeda, Debra A. Davis, Heather J. Elson, Amy N. Sussman

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The present study examined whether reserpine-induced oral dyskinesia is mediated by release of residual endogenous dopamine. Amphetamine produced a dose-dependent change in reserpine-induced oral dyskinesia in which the response was exacerbated by 0.6 mg/kg amphetamine and inhibited by 1 mg/kg. The latter dose also produced stereotypy that may have interfered with expression of reserpine-induced oral dyskinesia. Nigrostriatal 6-hydroxydopamine lesions attenuated expression of reserpine-induced oral dyskinesia. These lesions did not reduce locomotor activity, however, indicating that the attenuation of reserpine-induced oral dyskinesia was not due to a general depressant effect of the lesions on motor behavior. These results suggest that increasing dopamine release by administration of amphetamine exacerbates reserpine-induced oral dyskinesia, whereas decreasing the amount of releasable dopamine in the striatum by 6-hydroxydopamine lesions attenuates reserpine-induced oral dyskinesia. These findings may have implications for understanding tardive dyskinesia and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalEuropean Journal of Pharmacology
Volume305
Issue number1-3
DOIs
StatePublished - Jun 3 1996

Keywords

  • 6-hydroxydopamine
  • amphetamine
  • caudate-putamen
  • dopamine
  • nigrostriatal
  • oral dyskinesia
  • rat
  • reserpine
  • tardive dyskinesia
  • tongue protrusion

ASJC Scopus subject areas

  • Pharmacology

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