Effects of amphetamine and 6-hydroxydopamine lesions on reserpine-induced oral dyskinesia

Janet Neisewander, Edward Castañeda, Debra A. Davis, Heather J. Elson, Amy N. Sussman

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The present study examined whether reserpine-induced oral dyskinesia is mediated by release of residual endogenous dopamine. Amphetamine produced a dose-dependent change in reserpine-induced oral dyskinesia in which the response was exacerbated by 0.6 mg/kg amphetamine and inhibited by 1 mg/kg. The latter dose also produced stereotypy that may have interfered with expression of reserpine-induced oral dyskinesia. Nigrostriatal 6-hydroxydopamine lesions attenuated expression of reserpine-induced oral dyskinesia. These lesions did not reduce locomotor activity, however, indicating that the attenuation of reserpine-induced oral dyskinesia was not due to a general depressant effect of the lesions on motor behavior. These results suggest that increasing dopamine release by administration of amphetamine exacerbates reserpine-induced oral dyskinesia, whereas decreasing the amount of releasable dopamine in the striatum by 6-hydroxydopamine lesions attenuates reserpine-induced oral dyskinesia. These findings may have implications for understanding tardive dyskinesia and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia.

Original languageEnglish (US)
Pages (from-to)13-21
Number of pages9
JournalEuropean Journal of Pharmacology
Volume305
Issue number1-3
DOIs
StatePublished - Jun 3 1996

Fingerprint

Oxidopamine
Reserpine
Movement Disorders
Amphetamine
Dopamine
Dyskinesias
Levodopa
Locomotion

Keywords

  • 6-hydroxydopamine
  • amphetamine
  • caudate-putamen
  • dopamine
  • nigrostriatal
  • oral dyskinesia
  • rat
  • reserpine
  • tardive dyskinesia
  • tongue protrusion

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Effects of amphetamine and 6-hydroxydopamine lesions on reserpine-induced oral dyskinesia. / Neisewander, Janet; Castañeda, Edward; Davis, Debra A.; Elson, Heather J.; Sussman, Amy N.

In: European Journal of Pharmacology, Vol. 305, No. 1-3, 03.06.1996, p. 13-21.

Research output: Contribution to journalArticle

Neisewander, Janet ; Castañeda, Edward ; Davis, Debra A. ; Elson, Heather J. ; Sussman, Amy N. / Effects of amphetamine and 6-hydroxydopamine lesions on reserpine-induced oral dyskinesia. In: European Journal of Pharmacology. 1996 ; Vol. 305, No. 1-3. pp. 13-21.
@article{a3ae8f073d4544328354e51395823d71,
title = "Effects of amphetamine and 6-hydroxydopamine lesions on reserpine-induced oral dyskinesia",
abstract = "The present study examined whether reserpine-induced oral dyskinesia is mediated by release of residual endogenous dopamine. Amphetamine produced a dose-dependent change in reserpine-induced oral dyskinesia in which the response was exacerbated by 0.6 mg/kg amphetamine and inhibited by 1 mg/kg. The latter dose also produced stereotypy that may have interfered with expression of reserpine-induced oral dyskinesia. Nigrostriatal 6-hydroxydopamine lesions attenuated expression of reserpine-induced oral dyskinesia. These lesions did not reduce locomotor activity, however, indicating that the attenuation of reserpine-induced oral dyskinesia was not due to a general depressant effect of the lesions on motor behavior. These results suggest that increasing dopamine release by administration of amphetamine exacerbates reserpine-induced oral dyskinesia, whereas decreasing the amount of releasable dopamine in the striatum by 6-hydroxydopamine lesions attenuates reserpine-induced oral dyskinesia. These findings may have implications for understanding tardive dyskinesia and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia.",
keywords = "6-hydroxydopamine, amphetamine, caudate-putamen, dopamine, nigrostriatal, oral dyskinesia, rat, reserpine, tardive dyskinesia, tongue protrusion",
author = "Janet Neisewander and Edward Casta{\~n}eda and Davis, {Debra A.} and Elson, {Heather J.} and Sussman, {Amy N.}",
year = "1996",
month = "6",
day = "3",
doi = "10.1016/0014-2999(96)00155-0",
language = "English (US)",
volume = "305",
pages = "13--21",
journal = "European Journal of Pharmacology",
issn = "0014-2999",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Effects of amphetamine and 6-hydroxydopamine lesions on reserpine-induced oral dyskinesia

AU - Neisewander, Janet

AU - Castañeda, Edward

AU - Davis, Debra A.

AU - Elson, Heather J.

AU - Sussman, Amy N.

PY - 1996/6/3

Y1 - 1996/6/3

N2 - The present study examined whether reserpine-induced oral dyskinesia is mediated by release of residual endogenous dopamine. Amphetamine produced a dose-dependent change in reserpine-induced oral dyskinesia in which the response was exacerbated by 0.6 mg/kg amphetamine and inhibited by 1 mg/kg. The latter dose also produced stereotypy that may have interfered with expression of reserpine-induced oral dyskinesia. Nigrostriatal 6-hydroxydopamine lesions attenuated expression of reserpine-induced oral dyskinesia. These lesions did not reduce locomotor activity, however, indicating that the attenuation of reserpine-induced oral dyskinesia was not due to a general depressant effect of the lesions on motor behavior. These results suggest that increasing dopamine release by administration of amphetamine exacerbates reserpine-induced oral dyskinesia, whereas decreasing the amount of releasable dopamine in the striatum by 6-hydroxydopamine lesions attenuates reserpine-induced oral dyskinesia. These findings may have implications for understanding tardive dyskinesia and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia.

AB - The present study examined whether reserpine-induced oral dyskinesia is mediated by release of residual endogenous dopamine. Amphetamine produced a dose-dependent change in reserpine-induced oral dyskinesia in which the response was exacerbated by 0.6 mg/kg amphetamine and inhibited by 1 mg/kg. The latter dose also produced stereotypy that may have interfered with expression of reserpine-induced oral dyskinesia. Nigrostriatal 6-hydroxydopamine lesions attenuated expression of reserpine-induced oral dyskinesia. These lesions did not reduce locomotor activity, however, indicating that the attenuation of reserpine-induced oral dyskinesia was not due to a general depressant effect of the lesions on motor behavior. These results suggest that increasing dopamine release by administration of amphetamine exacerbates reserpine-induced oral dyskinesia, whereas decreasing the amount of releasable dopamine in the striatum by 6-hydroxydopamine lesions attenuates reserpine-induced oral dyskinesia. These findings may have implications for understanding tardive dyskinesia and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia.

KW - 6-hydroxydopamine

KW - amphetamine

KW - caudate-putamen

KW - dopamine

KW - nigrostriatal

KW - oral dyskinesia

KW - rat

KW - reserpine

KW - tardive dyskinesia

KW - tongue protrusion

UR - http://www.scopus.com/inward/record.url?scp=0343586513&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0343586513&partnerID=8YFLogxK

U2 - 10.1016/0014-2999(96)00155-0

DO - 10.1016/0014-2999(96)00155-0

M3 - Article

C2 - 8813526

AN - SCOPUS:0343586513

VL - 305

SP - 13

EP - 21

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

SN - 0014-2999

IS - 1-3

ER -