Abstract
The present study examined whether reserpine-induced oral dyskinesia is mediated by release of residual endogenous dopamine. Amphetamine produced a dose-dependent change in reserpine-induced oral dyskinesia in which the response was exacerbated by 0.6 mg/kg amphetamine and inhibited by 1 mg/kg. The latter dose also produced stereotypy that may have interfered with expression of reserpine-induced oral dyskinesia. Nigrostriatal 6-hydroxydopamine lesions attenuated expression of reserpine-induced oral dyskinesia. These lesions did not reduce locomotor activity, however, indicating that the attenuation of reserpine-induced oral dyskinesia was not due to a general depressant effect of the lesions on motor behavior. These results suggest that increasing dopamine release by administration of amphetamine exacerbates reserpine-induced oral dyskinesia, whereas decreasing the amount of releasable dopamine in the striatum by 6-hydroxydopamine lesions attenuates reserpine-induced oral dyskinesia. These findings may have implications for understanding tardive dyskinesia and L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia.
Original language | English (US) |
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Pages (from-to) | 13-21 |
Number of pages | 9 |
Journal | European Journal of Pharmacology |
Volume | 305 |
Issue number | 1-3 |
DOIs | |
State | Published - Jun 3 1996 |
Keywords
- 6-hydroxydopamine
- amphetamine
- caudate-putamen
- dopamine
- nigrostriatal
- oral dyskinesia
- rat
- reserpine
- tardive dyskinesia
- tongue protrusion
ASJC Scopus subject areas
- Pharmacology