TY - JOUR
T1 - Effects of a lifestyle intervention on markers of cardiometabolic risk and oxidized lipoproteins among obese adolescents with prediabetes
AU - Rentería-Mexía, Ana
AU - Vega-Lopez, Sonia
AU - Olson, Micah L.
AU - Swan, Pamela
AU - Lee, Chong
AU - Williams, Allison N.
AU - Shaibi, Gabriel
N1 - Funding Information:
The authors thank Ginger Hook, RN, Veronica Zamora, RT, and Mayra Arias-Gastelum, MSc, for their assistance with the study. They are grateful to the children and families who made this study possible. Financial support: This work was supported by the ASU Southwest Interdisciplinary Research Center, an Exploratory Center of Excellence for Health Disparities Research and Training, through a grant from the National Institutes of Health, National Institute on Minority Health and Health Disparities (grant number P20MD002316); and by the ASU Office of Knowledge Enterprise Development, Graduate and Professional Student Association, and the Graduate College. A.R.-M. was supported by the Programa para el Desarrollo Profesional Docente en Educacin Superior (PRODEP), Mxico, during her doctoral studies. The funders had no role in the design, analysis or writing of this article. Conflict of interest: None. Authorship: A.R.-M. contributed to the hypothesis development, data acquisition, analysis and interpretation, and manuscript preparation. S.V.-L. contributed to the hypothesis development, data analysis and interpretation, and manuscript revisions. M.L.O. contributed to data interpretation and manuscript revisions. P.D.S. contributed to data interpretation and manuscript revisions. C.D.L. contributed to the study design, statistical analysis, data interpretation and manuscript revisions. A.N.W. contributed to the hypothesis development, data interpretation and manuscript revisions. G.Q.S. contributed to the study design, hypothesis development, funding, supervision, data analysis, data interpretation and manuscript revisions. All authors read and approved the final manuscript. Ethics of human subject participation: This study was conducted according to the guidelines laid down in the Declaration of Helsinki and all procedures involving human subjects were approved by the Institutional Review Board from Arizona State University. Written parental consent and child assent were obtained prior to any data collection procedures.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Objective Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.Design Pre-post design.Setting Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.Participants Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (sd 1.0) years; mean BMI percentile 98.5 (sd 1.2)) with prediabetes.Results Intervention participation resulted in significant reductions in weight (-1.2 %, P = 0.042), BMI and BMI percentile (-2.0 and -0.4 %, respectively, P < 0.001), body fat (-7.0 %, P = 0.025), TAG (-11.8 %, P = 0.032), total cholesterol (-5.0 %, P = 0.002), VLDL-cholesterol (-12.5 %, P = 0.029), and non-HDL-cholesterol (-6.7 %, P = 0.007). Additionally, fitness (6.4 %, P < 0.001) and intake of fruits and vegetables (42.4 %, P = 0.025) increased significantly. OxLDL decreased significantly after the intervention (51.0 (sd 14.0) v. 48.7 (sd 12.8) U/l, P = 0.022), while oxHDL trended towards a significant increase (395.2 (sd 94.6) v. 416.1 (sd 98.4) ng/ml, P = 0.056).Conclusions These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
AB - Objective Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.Design Pre-post design.Setting Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.Participants Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (sd 1.0) years; mean BMI percentile 98.5 (sd 1.2)) with prediabetes.Results Intervention participation resulted in significant reductions in weight (-1.2 %, P = 0.042), BMI and BMI percentile (-2.0 and -0.4 %, respectively, P < 0.001), body fat (-7.0 %, P = 0.025), TAG (-11.8 %, P = 0.032), total cholesterol (-5.0 %, P = 0.002), VLDL-cholesterol (-12.5 %, P = 0.029), and non-HDL-cholesterol (-6.7 %, P = 0.007). Additionally, fitness (6.4 %, P < 0.001) and intake of fruits and vegetables (42.4 %, P = 0.025) increased significantly. OxLDL decreased significantly after the intervention (51.0 (sd 14.0) v. 48.7 (sd 12.8) U/l, P = 0.022), while oxHDL trended towards a significant increase (395.2 (sd 94.6) v. 416.1 (sd 98.4) ng/ml, P = 0.056).Conclusions These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
KW - Obese Latino adolescents
KW - Oxidized HDL
KW - Oxidized LDL
KW - Oxidized lipoproteins
KW - Prediabetes
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U2 - 10.1017/S1368980018003476
DO - 10.1017/S1368980018003476
M3 - Article
AN - SCOPUS:85063053466
VL - 22
SP - 706
EP - 713
JO - Public Health Nutrition
JF - Public Health Nutrition
SN - 1368-9800
IS - 4
ER -