Effects of a lifestyle intervention on markers of cardiometabolic risk and oxidized lipoproteins among obese adolescents with prediabetes

Ana Rentería-Mexía, Sonia Vega-Lopez, Micah L. Olson, Pamela Swan, Chong Lee, Allison N. Williams, Gabriel Shaibi

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Objective Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.Design Pre-post design.Setting Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.Participants Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (sd 1.0) years; mean BMI percentile 98.5 (sd 1.2)) with prediabetes.Results Intervention participation resulted in significant reductions in weight (-1.2 %, P = 0.042), BMI and BMI percentile (-2.0 and -0.4 %, respectively, P < 0.001), body fat (-7.0 %, P = 0.025), TAG (-11.8 %, P = 0.032), total cholesterol (-5.0 %, P = 0.002), VLDL-cholesterol (-12.5 %, P = 0.029), and non-HDL-cholesterol (-6.7 %, P = 0.007). Additionally, fitness (6.4 %, P < 0.001) and intake of fruits and vegetables (42.4 %, P = 0.025) increased significantly. OxLDL decreased significantly after the intervention (51.0 (sd 14.0) v. 48.7 (sd 12.8) U/l, P = 0.022), while oxHDL trended towards a significant increase (395.2 (sd 94.6) v. 416.1 (sd 98.4) ng/ml, P = 0.056).Conclusions These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)706-713
Number of pages8
JournalPublic Health Nutrition
Issue number4
StatePublished - Mar 1 2019


  • Obese Latino adolescents
  • Oxidized HDL
  • Oxidized LDL
  • Oxidized lipoproteins
  • Prediabetes

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Public Health, Environmental and Occupational Health


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