Abstract
Objective Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.Design Pre-post design.Setting Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.Participants Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (sd 1.0) years; mean BMI percentile 98.5 (sd 1.2)) with prediabetes.Results Intervention participation resulted in significant reductions in weight (-1.2 %, P = 0.042), BMI and BMI percentile (-2.0 and -0.4 %, respectively, P < 0.001), body fat (-7.0 %, P = 0.025), TAG (-11.8 %, P = 0.032), total cholesterol (-5.0 %, P = 0.002), VLDL-cholesterol (-12.5 %, P = 0.029), and non-HDL-cholesterol (-6.7 %, P = 0.007). Additionally, fitness (6.4 %, P < 0.001) and intake of fruits and vegetables (42.4 %, P = 0.025) increased significantly. OxLDL decreased significantly after the intervention (51.0 (sd 14.0) v. 48.7 (sd 12.8) U/l, P = 0.022), while oxHDL trended towards a significant increase (395.2 (sd 94.6) v. 416.1 (sd 98.4) ng/ml, P = 0.056).Conclusions These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 706-713 |
| Number of pages | 8 |
| Journal | Public Health Nutrition |
| Volume | 22 |
| Issue number | 4 |
| DOIs | |
| State | Published - Mar 1 2019 |
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Keywords
- Obese Latino adolescents
- Oxidized HDL
- Oxidized LDL
- Oxidized lipoproteins
- Prediabetes
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Public Health, Environmental and Occupational Health
Cite this
Effects of a lifestyle intervention on markers of cardiometabolic risk and oxidized lipoproteins among obese adolescents with prediabetes. / Rentería-Mexía, Ana; Vega-Lopez, Sonia; Olson, Micah L.; Swan, Pamela; Lee, Chong; Williams, Allison N.; Shaibi, Gabriel.
In: Public Health Nutrition, Vol. 22, No. 4, 01.03.2019, p. 706-713.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Effects of a lifestyle intervention on markers of cardiometabolic risk and oxidized lipoproteins among obese adolescents with prediabetes
AU - Rentería-Mexía, Ana
AU - Vega-Lopez, Sonia
AU - Olson, Micah L.
AU - Swan, Pamela
AU - Lee, Chong
AU - Williams, Allison N.
AU - Shaibi, Gabriel
PY - 2019/3/1
Y1 - 2019/3/1
N2 - Objective Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.Design Pre-post design.Setting Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.Participants Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (sd 1.0) years; mean BMI percentile 98.5 (sd 1.2)) with prediabetes.Results Intervention participation resulted in significant reductions in weight (-1.2 %, P = 0.042), BMI and BMI percentile (-2.0 and -0.4 %, respectively, P < 0.001), body fat (-7.0 %, P = 0.025), TAG (-11.8 %, P = 0.032), total cholesterol (-5.0 %, P = 0.002), VLDL-cholesterol (-12.5 %, P = 0.029), and non-HDL-cholesterol (-6.7 %, P = 0.007). Additionally, fitness (6.4 %, P < 0.001) and intake of fruits and vegetables (42.4 %, P = 0.025) increased significantly. OxLDL decreased significantly after the intervention (51.0 (sd 14.0) v. 48.7 (sd 12.8) U/l, P = 0.022), while oxHDL trended towards a significant increase (395.2 (sd 94.6) v. 416.1 (sd 98.4) ng/ml, P = 0.056).Conclusions These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
AB - Objective Obesity and hyperglycaemia contribute to the atherosclerotic process in part through oxidative modifications to lipoprotein particles. The present study aimed to evaluate the effects of a lifestyle intervention on markers of oxidized lipoproteins in obese Latino adolescents with prediabetes.Design Pre-post design.Setting Participants were enrolled into a 12-week lifestyle intervention. Measurements pre- and post-intervention included anthropometrics and body composition, lipid panel, oxidized LDL (oxLDL), oxidized HDL (oxHDL), intake of fresh fruits and vegetables, and cardiorespiratory fitness.Participants Thirty-five obese Latino adolescents (seventeen females, eighteen males; mean age 15.5 (sd 1.0) years; mean BMI percentile 98.5 (sd 1.2)) with prediabetes.Results Intervention participation resulted in significant reductions in weight (-1.2 %, P = 0.042), BMI and BMI percentile (-2.0 and -0.4 %, respectively, P < 0.001), body fat (-7.0 %, P = 0.025), TAG (-11.8 %, P = 0.032), total cholesterol (-5.0 %, P = 0.002), VLDL-cholesterol (-12.5 %, P = 0.029), and non-HDL-cholesterol (-6.7 %, P = 0.007). Additionally, fitness (6.4 %, P < 0.001) and intake of fruits and vegetables (42.4 %, P = 0.025) increased significantly. OxLDL decreased significantly after the intervention (51.0 (sd 14.0) v. 48.7 (sd 12.8) U/l, P = 0.022), while oxHDL trended towards a significant increase (395.2 (sd 94.6) v. 416.1 (sd 98.4) ng/ml, P = 0.056).Conclusions These data support the utility of lifestyle intervention to improve the atherogenic phenotype of Latino adolescents who are at high risk for developing premature CVD and type 2 diabetes.
KW - Obese Latino adolescents
KW - Oxidized HDL
KW - Oxidized LDL
KW - Oxidized lipoproteins
KW - Prediabetes
UR - http://www.scopus.com/inward/record.url?scp=85063053466&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063053466&partnerID=8YFLogxK
U2 - 10.1017/S1368980018003476
DO - 10.1017/S1368980018003476
M3 - Article
VL - 22
SP - 706
EP - 713
JO - Public Health Nutrition
JF - Public Health Nutrition
SN - 1368-9800
IS - 4
ER -