Effect of the injection solvent on steroid activity

P. Deviche, J. Balthazart

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

The effects of testosterone, 5α-dihydrotestosterone, and androstenedione on cloacal gland and sternotracheal muscle growth and on luteinizing hormone plasma levels were studied in Japanese quail. The steroids were given to the animals in daily intramuscular injections and were dissolved either in propylene glycol or in ethanol:saline (1:1). The three steroids had significant effects on the responses which were measured, but the magnitude of this effect was clearly related to the type of vehicle in which the steroids were dissolved. Furthermore there was a significant interaction between the effects of solvents and of steroid; for example, testosterone was much less androgenic than 5α-dihydrotestosterone when dissolved in propylene glycol, but both had similar effects when dissolved in ethanol:saline. The effects of the mode of administration of different steroids on a given physiological response should be taken into consideration.

Original languageEnglish (US)
Pages (from-to)199-202
Number of pages4
JournalGeneral and Comparative Endocrinology
Volume65
Issue number2
DOIs
StatePublished - Feb 1987
Externally publishedYes

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ASJC Scopus subject areas

  • Animal Science and Zoology
  • Endocrinology

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