Effect of schedule of reinforcement on cue-elicited reinstatement of cocaine-seeking behavior

Jazmin I. Acosta, Kenneth J. Thiel, Federico Sanabria, Jenny R. Browning, Janet Neisewander

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Cocaine-associated cues can elicit incentive motivational effects that drive cocaine-seeking behavior and contribute to relapse. The extinction/reinstatement model is commonly used to measure these effects in animals. This study examined the influence of training and testing schedules of reinforcement on cue-elicited reinstatement. Lever presses during training resulted in cues and cocaine (0.75 mg/kg/IV) on either continuous or partial reinforcement schedules [fixed ratio (FR) 1 or 11, variable ratio (VR) 5 or 11]. Animals then underwent extinction training, followed by a test for cue-elicited reinstatement of extinguished cocaine-seeking behavior by response-contingent cue presentations on either a continuous (FR 1) or a partial reinforcement schedule (FR 11). Partial reinforcement during training resulted in higher response rates during cue-elicited reinstatement relative to continuous reinforcement. In contrast, delivery of cues on a continuous reinforcement schedule during testing yielded higher response rates relative to delivery on a partial reinforcement schedule. Finally, the shift from a partial to a continuous reinforcement schedule across training and testing phases did not alter response rates. These findings provide important information for choosing parameters for reinstatement of drug-seeking behavior that would allow the most sensitive method to detect changes in response rate after an experimental manipulation.

Original languageEnglish (US)
Pages (from-to)129-136
Number of pages8
JournalBehavioural Pharmacology
Volume19
Issue number2
DOIs
StatePublished - Mar 2008

Fingerprint

Reinforcement Schedule
Cocaine
Cues
Drug-Seeking Behavior
Motivation
Recurrence

Keywords

  • Conditioned reinforcement
  • Craving
  • Drug-seeking
  • Extinction
  • Partial reinforcement extinction effect
  • Rat
  • Relapse

ASJC Scopus subject areas

  • Pharmacology
  • Neuroscience(all)

Cite this

Effect of schedule of reinforcement on cue-elicited reinstatement of cocaine-seeking behavior. / Acosta, Jazmin I.; Thiel, Kenneth J.; Sanabria, Federico; Browning, Jenny R.; Neisewander, Janet.

In: Behavioural Pharmacology, Vol. 19, No. 2, 03.2008, p. 129-136.

Research output: Contribution to journalArticle

@article{d2d7bbf878d54f8aa8f48fe45cb50934,
title = "Effect of schedule of reinforcement on cue-elicited reinstatement of cocaine-seeking behavior",
abstract = "Cocaine-associated cues can elicit incentive motivational effects that drive cocaine-seeking behavior and contribute to relapse. The extinction/reinstatement model is commonly used to measure these effects in animals. This study examined the influence of training and testing schedules of reinforcement on cue-elicited reinstatement. Lever presses during training resulted in cues and cocaine (0.75 mg/kg/IV) on either continuous or partial reinforcement schedules [fixed ratio (FR) 1 or 11, variable ratio (VR) 5 or 11]. Animals then underwent extinction training, followed by a test for cue-elicited reinstatement of extinguished cocaine-seeking behavior by response-contingent cue presentations on either a continuous (FR 1) or a partial reinforcement schedule (FR 11). Partial reinforcement during training resulted in higher response rates during cue-elicited reinstatement relative to continuous reinforcement. In contrast, delivery of cues on a continuous reinforcement schedule during testing yielded higher response rates relative to delivery on a partial reinforcement schedule. Finally, the shift from a partial to a continuous reinforcement schedule across training and testing phases did not alter response rates. These findings provide important information for choosing parameters for reinstatement of drug-seeking behavior that would allow the most sensitive method to detect changes in response rate after an experimental manipulation.",
keywords = "Conditioned reinforcement, Craving, Drug-seeking, Extinction, Partial reinforcement extinction effect, Rat, Relapse",
author = "Acosta, {Jazmin I.} and Thiel, {Kenneth J.} and Federico Sanabria and Browning, {Jenny R.} and Janet Neisewander",
year = "2008",
month = "3",
doi = "10.1097/FBP.0b013e3282f62c89",
language = "English (US)",
volume = "19",
pages = "129--136",
journal = "Behavioural Pharmacology",
issn = "0955-8810",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Effect of schedule of reinforcement on cue-elicited reinstatement of cocaine-seeking behavior

AU - Acosta, Jazmin I.

AU - Thiel, Kenneth J.

AU - Sanabria, Federico

AU - Browning, Jenny R.

AU - Neisewander, Janet

PY - 2008/3

Y1 - 2008/3

N2 - Cocaine-associated cues can elicit incentive motivational effects that drive cocaine-seeking behavior and contribute to relapse. The extinction/reinstatement model is commonly used to measure these effects in animals. This study examined the influence of training and testing schedules of reinforcement on cue-elicited reinstatement. Lever presses during training resulted in cues and cocaine (0.75 mg/kg/IV) on either continuous or partial reinforcement schedules [fixed ratio (FR) 1 or 11, variable ratio (VR) 5 or 11]. Animals then underwent extinction training, followed by a test for cue-elicited reinstatement of extinguished cocaine-seeking behavior by response-contingent cue presentations on either a continuous (FR 1) or a partial reinforcement schedule (FR 11). Partial reinforcement during training resulted in higher response rates during cue-elicited reinstatement relative to continuous reinforcement. In contrast, delivery of cues on a continuous reinforcement schedule during testing yielded higher response rates relative to delivery on a partial reinforcement schedule. Finally, the shift from a partial to a continuous reinforcement schedule across training and testing phases did not alter response rates. These findings provide important information for choosing parameters for reinstatement of drug-seeking behavior that would allow the most sensitive method to detect changes in response rate after an experimental manipulation.

AB - Cocaine-associated cues can elicit incentive motivational effects that drive cocaine-seeking behavior and contribute to relapse. The extinction/reinstatement model is commonly used to measure these effects in animals. This study examined the influence of training and testing schedules of reinforcement on cue-elicited reinstatement. Lever presses during training resulted in cues and cocaine (0.75 mg/kg/IV) on either continuous or partial reinforcement schedules [fixed ratio (FR) 1 or 11, variable ratio (VR) 5 or 11]. Animals then underwent extinction training, followed by a test for cue-elicited reinstatement of extinguished cocaine-seeking behavior by response-contingent cue presentations on either a continuous (FR 1) or a partial reinforcement schedule (FR 11). Partial reinforcement during training resulted in higher response rates during cue-elicited reinstatement relative to continuous reinforcement. In contrast, delivery of cues on a continuous reinforcement schedule during testing yielded higher response rates relative to delivery on a partial reinforcement schedule. Finally, the shift from a partial to a continuous reinforcement schedule across training and testing phases did not alter response rates. These findings provide important information for choosing parameters for reinstatement of drug-seeking behavior that would allow the most sensitive method to detect changes in response rate after an experimental manipulation.

KW - Conditioned reinforcement

KW - Craving

KW - Drug-seeking

KW - Extinction

KW - Partial reinforcement extinction effect

KW - Rat

KW - Relapse

UR - http://www.scopus.com/inward/record.url?scp=40549108603&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549108603&partnerID=8YFLogxK

U2 - 10.1097/FBP.0b013e3282f62c89

DO - 10.1097/FBP.0b013e3282f62c89

M3 - Article

VL - 19

SP - 129

EP - 136

JO - Behavioural Pharmacology

JF - Behavioural Pharmacology

SN - 0955-8810

IS - 2

ER -