Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice

Qian Zhang, Minghua Hu, Lu Xu, Xiangliang Yang, Yung Chang, Yanhong Zhu

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Fungal polysaccharides have shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides in enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-γ in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines.

Original languageEnglish (US)
Pages (from-to)1-12
Number of pages12
JournalFood and Agricultural Immunology
DOIs
StateAccepted/In press - May 27 2017

Fingerprint

Fungal Polysaccharides
Influenza Vaccines
influenza
polysaccharides
vaccines
mice
Polysaccharides
Vaccines
Lentinan
Ants
Oral Administration
Immunity
Anti-Inflammatory Agents
Immunoglobulin G
rendering
Orthomyxoviridae
Cytokines
Viruses
Morbidity
Lung

Keywords

  • immune
  • influenza virus
  • Lentinan
  • pachymaran
  • tremellan

ASJC Scopus subject areas

  • Food Science
  • Immunology
  • Agronomy and Crop Science

Cite this

Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice. / Zhang, Qian; Hu, Minghua; Xu, Lu; Yang, Xiangliang; Chang, Yung; Zhu, Yanhong.

In: Food and Agricultural Immunology, 27.05.2017, p. 1-12.

Research output: Contribution to journalArticle

Zhang, Qian ; Hu, Minghua ; Xu, Lu ; Yang, Xiangliang ; Chang, Yung ; Zhu, Yanhong. / Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice. In: Food and Agricultural Immunology. 2017 ; pp. 1-12.
@article{88e96035ee954eae9b31cbb7fb546030,
title = "Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice",
abstract = "Fungal polysaccharides have shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides in enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-γ in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines.",
keywords = "immune, influenza virus, Lentinan, pachymaran, tremellan",
author = "Qian Zhang and Minghua Hu and Lu Xu and Xiangliang Yang and Yung Chang and Yanhong Zhu",
year = "2017",
month = "5",
day = "27",
doi = "10.1080/09540105.2017.1323326",
language = "English (US)",
pages = "1--12",
journal = "Food and Agricultural Immunology",
issn = "0954-0105",
publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Effect of edible fungal polysaccharides on improving influenza vaccine protection in mice

AU - Zhang, Qian

AU - Hu, Minghua

AU - Xu, Lu

AU - Yang, Xiangliang

AU - Chang, Yung

AU - Zhu, Yanhong

PY - 2017/5/27

Y1 - 2017/5/27

N2 - Fungal polysaccharides have shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides in enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-γ in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines.

AB - Fungal polysaccharides have shown broad spectrum of biological activities, including anti-inflammatory, ant-oxidative and improve immunity. However, oral administration of fungal polysaccharides for rendering the conventional vaccine against influenza virus has been reported rarely. Here, we investigated the potential of fungal polysaccharides in enhancing the influenza vaccine efficacy in a mouse model. Mice were immunized with inactivated H1N1 (A/PR8/1934) influenza vaccine combined with oral polysaccharides lentinan, tremellan, pachymaran and a mixture of the three. The results showed that mice in the polysaccharides/vaccine groups had reduced morbidity, improved viral clearance, and recovered faster than the mice receiving the conventional vaccine only after infection. This effect could be attributed to the increased levels of virus-specific serum antibody IgG and decreased levels of inflammatory cytokine IFN-γ in the lung tissue. Our finding suggests that taking fungal polysaccharides orally might be useful for improving the efficacy of conventional inactive influenza vaccines.

KW - immune

KW - influenza virus

KW - Lentinan

KW - pachymaran

KW - tremellan

UR - http://www.scopus.com/inward/record.url?scp=85019704012&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019704012&partnerID=8YFLogxK

U2 - 10.1080/09540105.2017.1323326

DO - 10.1080/09540105.2017.1323326

M3 - Article

AN - SCOPUS:85019704012

SP - 1

EP - 12

JO - Food and Agricultural Immunology

JF - Food and Agricultural Immunology

SN - 0954-0105

ER -