Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters

Brian R. Kupchak, Amy L. McKenzie, Hui Ying Luk, Cathy Saenz, Laura J. Kunces, Lindsay A. Ellis, Jakob L. Vingren, Elaine C. Lee, Kevin D. Ballard, Evan C. Johnson, Stavros A. Kavouras, Matthew S. Ganio, Jonathon E. Wingo, Keith H. Williamson, Lawrence E. Armstrong

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).

Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.

Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.

Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.

Original languageEnglish (US)
Pages (from-to)1295-1303
Number of pages9
JournalEuropean Journal of Applied Physiology
Volume115
Issue number6
DOIs
StatePublished - Jun 1 2015
Externally publishedYes

Fingerprint

Plasminogen Activator Inhibitor 1
Hot Temperature
von Willebrand Factor
Waist Circumference
Plasminogen Inactivators
Fibrinolysis
Tissue Plasminogen Activator
Hemostatics
Hemostasis
Platelet Count
Blood Platelets
Antigens
fibrin fragment D
prothrombin fragment 1
prothrombin fragment 2
antithrombin III-protease complex
Von Willebrand antigen

Keywords

  • Coagulation
  • Cycling
  • Fibrinolysis
  • Heat stress

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Public Health, Environmental and Occupational Health
  • Physiology (medical)

Cite this

Kupchak, B. R., McKenzie, A. L., Luk, H. Y., Saenz, C., Kunces, L. J., Ellis, L. A., ... Armstrong, L. E. (2015). Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters. European Journal of Applied Physiology, 115(6), 1295-1303. https://doi.org/10.1007/s00421-015-3107-y

Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters. / Kupchak, Brian R.; McKenzie, Amy L.; Luk, Hui Ying; Saenz, Cathy; Kunces, Laura J.; Ellis, Lindsay A.; Vingren, Jakob L.; Lee, Elaine C.; Ballard, Kevin D.; Johnson, Evan C.; Kavouras, Stavros A.; Ganio, Matthew S.; Wingo, Jonathon E.; Williamson, Keith H.; Armstrong, Lawrence E.

In: European Journal of Applied Physiology, Vol. 115, No. 6, 01.06.2015, p. 1295-1303.

Research output: Contribution to journalArticle

Kupchak, BR, McKenzie, AL, Luk, HY, Saenz, C, Kunces, LJ, Ellis, LA, Vingren, JL, Lee, EC, Ballard, KD, Johnson, EC, Kavouras, SA, Ganio, MS, Wingo, JE, Williamson, KH & Armstrong, LE 2015, 'Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters', European Journal of Applied Physiology, vol. 115, no. 6, pp. 1295-1303. https://doi.org/10.1007/s00421-015-3107-y
Kupchak, Brian R. ; McKenzie, Amy L. ; Luk, Hui Ying ; Saenz, Cathy ; Kunces, Laura J. ; Ellis, Lindsay A. ; Vingren, Jakob L. ; Lee, Elaine C. ; Ballard, Kevin D. ; Johnson, Evan C. ; Kavouras, Stavros A. ; Ganio, Matthew S. ; Wingo, Jonathon E. ; Williamson, Keith H. ; Armstrong, Lawrence E. / Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters. In: European Journal of Applied Physiology. 2015 ; Vol. 115, No. 6. pp. 1295-1303.
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abstract = "Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 {\%}), vWF:Ag (65 {\%}), PTF 1 + 2 (47 {\%}), TAT (81 {\%}), tPA Ag (231 {\%}), PAI-1 Ag (148 {\%}), and D-Dimer (54 {\%}). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.",
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T1 - Effect of cycling in the heat for 164 km on procoagulant and fibrinolytic parameters

AU - Kupchak, Brian R.

AU - McKenzie, Amy L.

AU - Luk, Hui Ying

AU - Saenz, Cathy

AU - Kunces, Laura J.

AU - Ellis, Lindsay A.

AU - Vingren, Jakob L.

AU - Lee, Elaine C.

AU - Ballard, Kevin D.

AU - Johnson, Evan C.

AU - Kavouras, Stavros A.

AU - Ganio, Matthew S.

AU - Wingo, Jonathon E.

AU - Williamson, Keith H.

AU - Armstrong, Lawrence E.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.

AB - Results: Compared to PRE, increases (p < 0.001) were observed at IP for platelets (39 %), vWF:Ag (65 %), PTF 1 + 2 (47 %), TAT (81 %), tPA Ag (231 %), PAI-1 Ag (148 %), and D-Dimer (54 %). PRE PAI-1 Ag concentrations were directly related to BMI and waist circumference (p < 0.05). D-Dimer concentrations at IP correlated positively with age (p < 0.05).Purpose: We assessed the impact of completing the Hotter’n Hell Hundred (HHH), an annual 164 km road cycling event performed in a hot environment, on hemostatic balance in men.Methods: Sixteen men who completed the ride in <6 h were included in this study. Plasma samples were collected on that morning of the ride (PRE) and immediately on the completion of the ride (IP). Primary hemostasis was assessed by platelet count and von Willebrand factor antigen (vWF:Ag). Coagulation was assessed by measuring prothrombin fragment 1 + 2 (PTF 1 + 2) and thrombin-antithrombin complex (TAT), whereas fibrinolysis was assessed by plasminogen activator inhibitor antigen (PAI-1 Ag), tissue plasminogen activator (tPA Ag), and D-Dimer analyses.Conclusions: Completing the HHH activated the coagulation and fibrinolytic systems in balance. Age was positively correlated with IP D-Dimer concentrations. Additionally, participants displaying a larger BMI and waist circumference exhibited a positive correlation with PRE PAI-1 Ag concentrations.

KW - Coagulation

KW - Cycling

KW - Fibrinolysis

KW - Heat stress

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