Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors

G. C. Jones, Denis Cortese, H. B. Neel

Research output: Contribution to journalArticle

Abstract

Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.

Original languageEnglish (US)
Pages (from-to)941-944
Number of pages4
JournalAnnals of Otology, Rhinology and Laryngology
Volume99
Issue number12
StatePublished - 1990
Externally publishedYes

Fingerprint

Hematoporphyrin Derivative
Phototherapy
Bleomycin
Squamous Cell Neoplasms
Neoplasms
Antineoplastic Antibiotics
Drug Therapy
Singlet Oxygen
Glycopeptides
Reactive Oxygen Species

Keywords

  • Hematoporphyrin derivative phototherapy
  • Laser therapy
  • Photodynamic therapy
  • Photoradiation therapy

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors. / Jones, G. C.; Cortese, Denis; Neel, H. B.

In: Annals of Otology, Rhinology and Laryngology, Vol. 99, No. 12, 1990, p. 941-944.

Research output: Contribution to journalArticle

@article{bf3107df19374b43b36bfbc5a5b17999,
title = "Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors",
abstract = "Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.",
keywords = "Hematoporphyrin derivative phototherapy, Laser therapy, Photodynamic therapy, Photoradiation therapy",
author = "Jones, {G. C.} and Denis Cortese and Neel, {H. B.}",
year = "1990",
language = "English (US)",
volume = "99",
pages = "941--944",
journal = "Annals of Otology, Rhinology and Laryngology",
issn = "0003-4894",
publisher = "Annals Publishing Company",
number = "12",

}

TY - JOUR

T1 - Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors

AU - Jones, G. C.

AU - Cortese, Denis

AU - Neel, H. B.

PY - 1990

Y1 - 1990

N2 - Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.

AB - Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.

KW - Hematoporphyrin derivative phototherapy

KW - Laser therapy

KW - Photodynamic therapy

KW - Photoradiation therapy

UR - http://www.scopus.com/inward/record.url?scp=0025685561&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025685561&partnerID=8YFLogxK

M3 - Article

C2 - 1700892

AN - SCOPUS:0025685561

VL - 99

SP - 941

EP - 944

JO - Annals of Otology, Rhinology and Laryngology

JF - Annals of Otology, Rhinology and Laryngology

SN - 0003-4894

IS - 12

ER -