Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors

Gregory C. Jones; Denis A. Cortese; H. Bryan Neel

doi:10.1177/000348949009901202

Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors

Gregory C. Jones, Denis A. Cortese, H. Bryan Neel

Research output: Contribution to journal › Article › peer-review

Abstract

Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.

Original language	English (US)
Pages (from-to)	941-944
Number of pages	4
Journal	Annals of Otology, Rhinology & Laryngology
Volume	99
Issue number	12
DOIs	https://doi.org/10.1177/000348949009901202
State	Published - Dec 1990
Externally published	Yes

Keywords

hematoporphyrin derivative phototherapy
laser therapy
photodynamic therapy
photoradiation therapy

ASJC Scopus subject areas

Otorhinolaryngology

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10.1177/000348949009901202

Cite this

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title = "Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors",

abstract = "Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.",

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author = "Jones, {Gregory C.} and Cortese, {Denis A.} and Neel, {H. Bryan}",

year = "1990",

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T1 - Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors

AU - Jones, Gregory C.

AU - Cortese, Denis A.

AU - Neel, H. Bryan

PY - 1990/12

Y1 - 1990/12

N2 - Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.

AB - Hematoporphyrin derivative phototherapy (HpD-PT) has been successfully used to localize and treat superficial squamous cell cancers. Bleomycin sulfate is a glycopeptide antibiotic that has antineoplastic properties against squamous cell cancers. Because both HpD-PT and bleomycin chemotherapy are accepted forms of treatment for squamous cell cancer and their cytotoxicity is mediated by singlet oxygen and oxygen radicals, we studied the possibility of enhancing the response of solid tumors to HpD-PT by combining this modality with systemic bleomycin chemotherapy in a murine tumor model. Bleomycin did not enhance HpD-PT significantly. Also, we are not confident that HpD-PT alone or in combination with other agents can eradicate solid tumors; it certainly did not in this syngeneic murine tumor model.

KW - hematoporphyrin derivative phototherapy

KW - laser therapy

KW - photodynamic therapy

KW - photoradiation therapy

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ER -

Effect of bleomycin on hematoporphyrin derivative phototherapy of solid tumors

Abstract

Keywords

ASJC Scopus subject areas

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