Effect of albendazole in experimental toxocariasis of mice

O. Delgado, C. Botto, R. Mattei, A. Escalante

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Fifty-five mice were each infected with 800 embryonated eggs of Toxocara canis. Beginning on the second day of the infection, one group received a single 9 mg dose of albendazole every 24 hours for an eight day period while a second group received 3 mg of albendazole every eight hours for the same period.On the tenth day of infection, mice in each treatment group and their corresponding controls were sacrificed, and the prescence and motility of T. canis larvae in the brain were determined. With both therapeutical procedures the administration of albendazole reduced the number of larvae which reach the brain. However, for the same total dose the administration of the drug every eight hours yielded results which were significantly superior to those produced by administering a single dose every 24 hours, reducing both the number of larvae in the brain and their motility

Original languageEnglish (US)
Pages (from-to)621-624
Number of pages4
JournalAnnals of Tropical Medicine and Parasitology
Volume83
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Toxocariasis
Albendazole
Toxocara canis
Larva
Brain
Infection
Eggs
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Immunology

Cite this

Delgado, O., Botto, C., Mattei, R., & Escalante, A. (1989). Effect of albendazole in experimental toxocariasis of mice. Annals of Tropical Medicine and Parasitology, 83(6), 621-624.

Effect of albendazole in experimental toxocariasis of mice. / Delgado, O.; Botto, C.; Mattei, R.; Escalante, A.

In: Annals of Tropical Medicine and Parasitology, Vol. 83, No. 6, 1989, p. 621-624.

Research output: Contribution to journalArticle

Delgado, O, Botto, C, Mattei, R & Escalante, A 1989, 'Effect of albendazole in experimental toxocariasis of mice', Annals of Tropical Medicine and Parasitology, vol. 83, no. 6, pp. 621-624.
Delgado, O. ; Botto, C. ; Mattei, R. ; Escalante, A. / Effect of albendazole in experimental toxocariasis of mice. In: Annals of Tropical Medicine and Parasitology. 1989 ; Vol. 83, No. 6. pp. 621-624.
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