Editorial

Itching to Know: Role of Fibrates in PBC

Cynthia Levy, Keith Lindor

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Approximately one-third of patients with primary biliary cholangitis (PBC) fail to respond to ursodeoxycholic acid (UDCA) and are at risk for progression to biliary cirrhosis and end-stage liver disease. In this paper by Pares et al., the authors evaluate the effect of long-term use of bezafibrate in patients with primary biliary cholangitis (PBC) and inadequate response to UDCA. They found that addition of bezafibrate led to normalization of serum alkaline phosphatase in half of the study subjects and major improvement in pruritus. Here we discuss these findings and place them in context with current knowledge about fibrates in PBC.

Original languageEnglish (US)
Pages (from-to)56-57
Number of pages2
JournalThe American journal of gastroenterology
Volume113
Issue number1
DOIs
StatePublished - Jan 1 2018

Fingerprint

Fibric Acids
Cholangitis
Pruritus
Bezafibrate
Ursodeoxycholic Acid
End Stage Liver Disease
Biliary Liver Cirrhosis
Alkaline Phosphatase
Serum

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

Cite this

Editorial : Itching to Know: Role of Fibrates in PBC. / Levy, Cynthia; Lindor, Keith.

In: The American journal of gastroenterology, Vol. 113, No. 1, 01.01.2018, p. 56-57.

Research output: Contribution to journalArticle

@article{bf0e481411474e7da6638fd4bd85ad8d,
title = "Editorial: Itching to Know: Role of Fibrates in PBC",
abstract = "Approximately one-third of patients with primary biliary cholangitis (PBC) fail to respond to ursodeoxycholic acid (UDCA) and are at risk for progression to biliary cirrhosis and end-stage liver disease. In this paper by Pares et al., the authors evaluate the effect of long-term use of bezafibrate in patients with primary biliary cholangitis (PBC) and inadequate response to UDCA. They found that addition of bezafibrate led to normalization of serum alkaline phosphatase in half of the study subjects and major improvement in pruritus. Here we discuss these findings and place them in context with current knowledge about fibrates in PBC.",
author = "Cynthia Levy and Keith Lindor",
year = "2018",
month = "1",
day = "1",
doi = "10.1038/ajg.2017.432",
language = "English (US)",
volume = "113",
pages = "56--57",
journal = "American Journal of Gastroenterology",
issn = "0002-9270",
publisher = "Nature Publishing Group",
number = "1",

}

TY - JOUR

T1 - Editorial

T2 - Itching to Know: Role of Fibrates in PBC

AU - Levy, Cynthia

AU - Lindor, Keith

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Approximately one-third of patients with primary biliary cholangitis (PBC) fail to respond to ursodeoxycholic acid (UDCA) and are at risk for progression to biliary cirrhosis and end-stage liver disease. In this paper by Pares et al., the authors evaluate the effect of long-term use of bezafibrate in patients with primary biliary cholangitis (PBC) and inadequate response to UDCA. They found that addition of bezafibrate led to normalization of serum alkaline phosphatase in half of the study subjects and major improvement in pruritus. Here we discuss these findings and place them in context with current knowledge about fibrates in PBC.

AB - Approximately one-third of patients with primary biliary cholangitis (PBC) fail to respond to ursodeoxycholic acid (UDCA) and are at risk for progression to biliary cirrhosis and end-stage liver disease. In this paper by Pares et al., the authors evaluate the effect of long-term use of bezafibrate in patients with primary biliary cholangitis (PBC) and inadequate response to UDCA. They found that addition of bezafibrate led to normalization of serum alkaline phosphatase in half of the study subjects and major improvement in pruritus. Here we discuss these findings and place them in context with current knowledge about fibrates in PBC.

UR - http://www.scopus.com/inward/record.url?scp=85061570930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061570930&partnerID=8YFLogxK

U2 - 10.1038/ajg.2017.432

DO - 10.1038/ajg.2017.432

M3 - Article

VL - 113

SP - 56

EP - 57

JO - American Journal of Gastroenterology

JF - American Journal of Gastroenterology

SN - 0002-9270

IS - 1

ER -