Early prediction of the Alzheimer's disease risk using Tau-PET and machine learning

Lujia Wang, Zhiyang Zheng, Yi Su, Kewei Chen, David A. Weidman, Teresa Wu, Ben Lo, Fleming Lure, Jing Li

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Alzheimer's Disease (AD) is a devastating neurodegenerative disease. Recent advances in tau-positron emission tomography (PET) imaging allow quantitating and mapping out the regional distribution of one important hallmark of AD across the brain. There is a need to develop machine learning (ML) algorithms to interrogate the utility of this new imaging modality. While there are some recent studies showing promise of using ML to differentiate AD patients from normal controls (NC) based on tau-PET images, there is limited work to investigate if tau-PET, with the help of ML, can facilitate predicting the risk of converting to AD while an individual is still at the early Mild Cognitive Impairment (MCI) stage. We developed an early AD risk predictor for subjects with MCI based on tau-PET using Machine Learning (ML). Our ML algorithms achieved good accuracy in predicting the risk of conversion to AD for a given MCI subject. Important features contributing to the prediction are consistent with literature reports of tau susceptible regions. This work demonstrated the feasibility of developing an early AD risk predictor for subjects with MCI based on tau-PET and ML.

Original languageEnglish (US)
Title of host publicationMedical Imaging 2022
Subtitle of host publicationComputer-Aided Diagnosis
EditorsKaren Drukker, Khan M. Iftekharuddin
PublisherSPIE
ISBN (Electronic)9781510649415
DOIs
StatePublished - 2022
Externally publishedYes
EventMedical Imaging 2022: Computer-Aided Diagnosis - Virtual, Online
Duration: Mar 21 2022Mar 27 2022

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume12033
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2022: Computer-Aided Diagnosis
CityVirtual, Online
Period3/21/223/27/22

Keywords

  • Alzheimer s disease
  • early detection
  • machine learning
  • mild cognitive impairment
  • risk prediction
  • tau-PET

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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