Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats

Candace R. Lewis, Kelsey Staudinger, Seven E. Tomek, Raymundo Hernandez, Tawny Manning, Michael Olive

Research output: Contribution to journalArticle

8 Scopus citations


Early life stress interacts with adult stress to differentially modulate neural systems and vulnerability to various psychiatric illnesses. However, the effects of early life stress and adult stress on addictive behaviors have not been sufficiently investigated. We examined the effects of early life stress in the form of prolonged maternal separation, followed in early adulthood by either 10 days of chronic variable stress or no stress, on methamphetamine selfadministration, extinction, and cue-induced reinstatement. We observed that chronic variable stress in adulthood reduced methamphetamine self-administration in rats with a history of early life stress. These findings add to an emerging body of literature suggesting interactions between early life and early adulthood stressors on adult behavioral phenotypes.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalBehavioural Pharmacology
Issue number2-3
StatePublished - Apr 1 2016



  • Addiction
  • Chronic variable stress
  • Early life stress
  • Maternal separation
  • Methamphetamine
  • Rat
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

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