Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats

Candace R. Lewis, Kelsey Staudinger, Seven E. Tomek, Raymundo Hernandez, Tawny Manning, Michael Olive

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Early life stress interacts with adult stress to differentially modulate neural systems and vulnerability to various psychiatric illnesses. However, the effects of early life stress and adult stress on addictive behaviors have not been sufficiently investigated. We examined the effects of early life stress in the form of prolonged maternal separation, followed in early adulthood by either 10 days of chronic variable stress or no stress, on methamphetamine selfadministration, extinction, and cue-induced reinstatement. We observed that chronic variable stress in adulthood reduced methamphetamine self-administration in rats with a history of early life stress. These findings add to an emerging body of literature suggesting interactions between early life and early adulthood stressors on adult behavioral phenotypes.

Original languageEnglish (US)
Pages (from-to)182-184
Number of pages3
JournalBehavioural Pharmacology
Volume27
Issue number2-3
DOIs
StatePublished - Apr 1 2016

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Self Administration
Methamphetamine
Psychological Stress
Addictive Behavior
Cues
Psychiatry
Mothers
Phenotype

Keywords

  • Addiction
  • Chronic variable stress
  • Early life stress
  • Maternal separation
  • Methamphetamine
  • Rat
  • Self-administration

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health

Cite this

Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats. / Lewis, Candace R.; Staudinger, Kelsey; Tomek, Seven E.; Hernandez, Raymundo; Manning, Tawny; Olive, Michael.

In: Behavioural Pharmacology, Vol. 27, No. 2-3, 01.04.2016, p. 182-184.

Research output: Contribution to journalArticle

Lewis, Candace R. ; Staudinger, Kelsey ; Tomek, Seven E. ; Hernandez, Raymundo ; Manning, Tawny ; Olive, Michael. / Early life stress and chronic variable stress in adulthood interact to influence methamphetamine self-administration in male rats. In: Behavioural Pharmacology. 2016 ; Vol. 27, No. 2-3. pp. 182-184.
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