TY - JOUR
T1 - Early detection and tracking of bulbar changes in ALS via frequent and remote speech analysis
AU - Stegmann, Gabriela M.
AU - Hahn, Shira
AU - Liss, Julie
AU - Shefner, Jeremy
AU - Rutkove, Seward
AU - Shelton, Kerisa
AU - Duncan, Cayla Jessica
AU - Berisha, Visar
N1 - Funding Information:
This work was supported by NIH SBIR (1R43DC017625-01), NSF SBIR (1853247), and NIH R01 (5R01DC006859-13).
Funding Information:
V.B. and J.L. are co-founders of Aural Analytics. J.S. is a scientific advisor to Aural Analytics. G.S. and S.H. are employed by Aural Analytics. This work was supported by NIH SBIR (1R43DC017625-01), NSF SBIR (1853247), and NIH R01 (5R01DC006859-13).
Publisher Copyright:
© 2020, The Author(s).
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally.
AB - Bulbar deterioration in amyotrophic lateral sclerosis (ALS) is a devastating characteristic that impairs patients’ ability to communicate, and is linked to shorter survival. The existing clinical instruments for assessing bulbar function lack sensitivity to early changes. In this paper, using a cohort of N = 65 ALS patients who provided regular speech samples for 3–9 months, we demonstrated that it is possible to remotely detect early speech changes and track speech progression in ALS via automated algorithmic assessment of speech collected digitally.
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U2 - 10.1038/s41746-020-00335-x
DO - 10.1038/s41746-020-00335-x
M3 - Article
AN - SCOPUS:85092497531
SN - 2398-6352
VL - 3
JO - npj Digital Medicine
JF - npj Digital Medicine
IS - 1
M1 - 132
ER -