Dynamics of two-phase lipid vesicles: Effects of mechanical properties on morphology evolution

Chloe M. Funkhouser, Francisco Solis, K. Thornton

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Multicomponent lipid vesicles can exhibit phase separation of coexisting liquid phases with different mechanical properties, leading to the formation of complex phase morphologies and membrane shapes. We examine the phase separation and the corresponding morphological and geometric evolution in two-phase lipid membrane vesicles using a phase-field method. We investigate the effects of the phase fraction as well as the mechanical properties of each phase on the evolution of the system while conserving surface area and composition. We contrast results for a flexible membrane with those obtained for a fixed spherical geometry with no mechanical coupling. We find that the coupling of bending energy with composition results in slower coarsening and that the phase with spontaneous curvature more similar to the average curvature of the vesicle is favored to form bicontinuous morphologies.

Original languageEnglish (US)
Pages (from-to)3462-3466
Number of pages5
JournalSoft Matter
Volume6
Issue number15
DOIs
StatePublished - Aug 7 2010

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Phase separation
lipids
mechanical properties
membranes
Membranes
Lipids
Mechanical properties
Coarsening
Membrane Lipids
Chemical analysis
curvature
Geometry
liquid phases
Liquids
geometry
energy

ASJC Scopus subject areas

  • Chemistry(all)
  • Condensed Matter Physics

Cite this

Dynamics of two-phase lipid vesicles : Effects of mechanical properties on morphology evolution. / Funkhouser, Chloe M.; Solis, Francisco; Thornton, K.

In: Soft Matter, Vol. 6, No. 15, 07.08.2010, p. 3462-3466.

Research output: Contribution to journalArticle

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