Dynamics of linear protein polymer disassembly.

D. Kristofferson, T. L. Karr, D. L. Purich

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

This report presents a kinetic model for endwise depolymerization of linear, self-assembling protein systems. We develop a reliable method for predicting the shape of depolymerization curves (remaining polymer weight versus time) on the basis of the initial polymer length distribution. Computer simulations are used to illustrate changes in the polymer length distribution and average polymer weight during disassembly. In addition, our method provides an accurate determination of the microscopic rate constant for subunit release. Application of this analysis to dilution-induced and cold induced disassembly of microtubules is illustrated in the preceding paper (Karr, T.L., Kristofferson, D., and Purich, D.L. (1980) J. Biol. Chem. 255, 8560-8566). A survey of other possible applications of this treatment to microtubules, flagella, F-actin, and tobacco mosaic virus protein is included.

Original languageEnglish (US)
Pages (from-to)8567-8572
Number of pages6
JournalJournal of Biological Chemistry
Volume255
Issue number18
StatePublished - Sep 25 1980
Externally publishedYes

Fingerprint

Polymers
Depolymerization
Microtubules
Proteins
Tobacco Mosaic Virus
Weights and Measures
Tobacco
Flagella
Viruses
Computer Simulation
Dilution
Actins
Rate constants
Kinetics
Computer simulation

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Kristofferson, D., Karr, T. L., & Purich, D. L. (1980). Dynamics of linear protein polymer disassembly. Journal of Biological Chemistry, 255(18), 8567-8572.

Dynamics of linear protein polymer disassembly. / Kristofferson, D.; Karr, T. L.; Purich, D. L.

In: Journal of Biological Chemistry, Vol. 255, No. 18, 25.09.1980, p. 8567-8572.

Research output: Contribution to journalArticle

Kristofferson, D, Karr, TL & Purich, DL 1980, 'Dynamics of linear protein polymer disassembly.', Journal of Biological Chemistry, vol. 255, no. 18, pp. 8567-8572.
Kristofferson D, Karr TL, Purich DL. Dynamics of linear protein polymer disassembly. Journal of Biological Chemistry. 1980 Sep 25;255(18):8567-8572.
Kristofferson, D. ; Karr, T. L. ; Purich, D. L. / Dynamics of linear protein polymer disassembly. In: Journal of Biological Chemistry. 1980 ; Vol. 255, No. 18. pp. 8567-8572.
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