Dynamics in rhodopsin

Research output: Contribution to journalShort surveypeer-review

21 Scopus citations

Abstract

Dancing in the dark: Much is known about the structure and light-induced conformational changes of the mammalian dimlight receptor rhodopsin, a model system for the entire G-protein-coupled receptor family. Less attention has been paid to the dynamic properties of rhodopsin. Growing evidence for the presence of large backbone motions in the inactive dark-state conformation of rhodopsin and their importance for the functional, light-induced conformational changes necessary for signal transduction are reviewed here. Cysteine mutagenesis experiments and spectroscopic techniques are combined to reveal more information about the protein dynamics.

Original languageEnglish (US)
Pages (from-to)981-986
Number of pages6
JournalChemBioChem
Volume3
Issue number10
DOIs
StatePublished - Oct 4 2002
Externally publishedYes

Keywords

  • Activation mechanism
  • Conformation analysis
  • G-protein-coupled receptors
  • Helical structures
  • Membrane proteins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Dynamics in rhodopsin'. Together they form a unique fingerprint.

Cite this