Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization

Qihui Fan, Yu Zheng, Xiaochen Wang, Ruipei Xie, Yu Ding, Boyi Wang, Xiaoyu Yu, Ying Lu, Liyu Liu, Yunliang Li, Ming Li, Yuanjin Zhao, Yang Jiao, Fangfu Ye

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Correlated cell migration in fibrous extracellular matrix (ECM) is important in many biological processes. During migration, cells can remodel the ECM, leading to the formation of mesoscale structures such as fiber bundles. However, how such mesoscale structures regulate correlated single-cells migration remains to be elucidated. Here, using a quasi-3D in vitro model, we investigate how collagen fiber bundles are dynamically re-organized and guide cell migration. By combining laser ablation technique with 3D tracking and active-particle simulations, we definitively show that only the re-organized fiber bundles that carry significant tensile forces can guide strongly correlated cell migration, providing for the first time a direct experimental evidence supporting that matrix-transmitted long-range forces can regulate cell migration and self-organization. This force regulation mechanism can provide new insights for studies on cellular dynamics, fabrication or selection of biomedical materials in tissue repairing, and many other biomedical applications.

Original languageEnglish (US)
Pages (from-to)11858-11867
Number of pages10
JournalAngewandte Chemie - International Edition
Volume60
Issue number21
DOIs
StatePublished - May 17 2021

Keywords

  • biological activity
  • collagen fiber bundles
  • correlated cell migration
  • fibrous proteins
  • long-range force propagation

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Dynamically Re-Organized Collagen Fiber Bundles Transmit Mechanical Signals and Induce Strongly Correlated Cell Migration and Self-Organization'. Together they form a unique fingerprint.

Cite this