Dynamic Gain Control of Dopamine Delivery in Freely Moving Animals

P. Read Montague, Samuel M. McClure, P. R. Baldwin, Paul E.M. Phillips, Evgeny A. Budygin, Garret D. Stuber, Michaux R. Kilpatrick, R. Mark Wightman

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

Activity changes in a large subset of midbrain dopamine neurons fulfill numerous assumptions of learning theory by encoding a prediction error between actual and predicted reward. This computational interpretation of dopaminergic spike activity invites the important question of how changes in spike rate are translated into changes in dopamine delivery at target neural structures. Using electrochemical detection of rapid dopamine release in the striatum of freely moving rats, we established that a single dynamic model can capture all the measured fluctuations in dopamine delivery. This model revealed three independent short-term adaptive processes acting to control dopamine release. These short-term components generalized well across animals and stimulation patterns and were preserved under anesthesia. The model has implications for the dynamic filtering interposed between changes in spike production and forebrain dopamine release.

Original languageEnglish (US)
Pages (from-to)1754-1759
Number of pages6
JournalJournal of Neuroscience
Volume24
Issue number7
DOIs
StatePublished - Feb 18 2004
Externally publishedYes

Keywords

  • Depression
  • Dopamine
  • Facilitation
  • Plasticity
  • Reward
  • Voltammetry

ASJC Scopus subject areas

  • Neuroscience(all)

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