dSno facilitates baboon signaling in the drosophila brain by switching the affinity of medea away from Mad and toward dSmad2

Norma T. Takaesu, Cathy Hyman-Walsh, Ying Ye, Robert G. Wisotzkey, Michael J. Stinchfield, Michael B. O'Connor, David Wotton, Stuart Newfeld

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A screen for modifiers of Dpp adult phenotypes led to the identification of the Drosophila homolog of the Sno oncogene (dSno). The dSno locus is large, transcriptionally complex and contains a recent retrotransposon insertion that may be essential for dSno function, an intriguing possibility from the perspective of developmental evolution. dSno is highly transcribed in the embryonic central nervous system and transcripts are most abundant in third instar larvae. dSno mutant larvae have proliferation defects in the optic lobe of the brain very similar to those seen in baboon (Activin type I receptor) and dSmad2 mutants. This suggests that dSno is a mediator of Baboon signaling. dSno binds to Medea and Medea/dSno complexes have enhanced affinity for dSmad2. Alternatively, Medea/dSno complexes have reduced affinity for Mad such that, in the presence of dSno, Dpp signaling is antagonized. We propose that dSno functions as a switch in optic lobe development, shunting Medea from the Dpp pathway to the Activin pathway to ensure proper proliferation. Pathway switching in target cells is a previously unreported mechanism for regulating TGFβ signaling and a novel function for Sno/Ski family proteins.

Original languageEnglish (US)
Pages (from-to)1299-1313
Number of pages15
JournalGenetics
Volume174
Issue number3
DOIs
StatePublished - Nov 29 2006

ASJC Scopus subject areas

  • Genetics

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    Takaesu, N. T., Hyman-Walsh, C., Ye, Y., Wisotzkey, R. G., Stinchfield, M. J., O'Connor, M. B., Wotton, D., & Newfeld, S. (2006). dSno facilitates baboon signaling in the drosophila brain by switching the affinity of medea away from Mad and toward dSmad2. Genetics, 174(3), 1299-1313. https://doi.org/10.1534/genetics.106.064956