Abstract
We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the INK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-β growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.
Original language | English (US) |
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Pages (from-to) | 1728-1737 |
Number of pages | 10 |
Journal | Genes and Development |
Volume | 11 |
Issue number | 13 |
DOIs | |
State | Published - Jul 1 1997 |
Keywords
- Dorsal closure
- Dpp
- Drosophila Jun
- JNK
- Signal relay
- jun
ASJC Scopus subject areas
- Genetics
- Developmental Biology