Drosophila jun relays the jun amino-terminal kinase signal transduction pathway to the decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement

X. Steven Hou, Elliott S. Goldstein, Norbert Perrimon

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

We have characterized mutations in the Drosophila homolog of the mammalian proto-oncogene c-Jun gene (Djun). We demonstrate that DJUN in the embryo is a downstream target of the INK signal transduction pathway during dorsal closure formation, and that the function of the JNK/DJUN pathway is to control the localized expression of decapentalegic (dpp), a member of the TGF-β growth factor family. In contrast to previous observations, we find that both in the embryo and during photoreceptor cell determination, DJUN is not regulated by a pathway that involves MAPK.

Original languageEnglish (US)
Pages (from-to)1728-1737
Number of pages10
JournalGenes and Development
Volume11
Issue number13
DOIs
StatePublished - Jul 1 1997

Keywords

  • Dorsal closure
  • Dpp
  • Drosophila Jun
  • JNK
  • Signal relay
  • jun

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

Fingerprint Dive into the research topics of 'Drosophila jun relays the jun amino-terminal kinase signal transduction pathway to the decapentaplegic signal transduction pathway in regulating epithelial cell sheet movement'. Together they form a unique fingerprint.

Cite this