Drosophila gene expression pattern annotation through multi-instance multi-label learning

Ying Xin Li, Shuiwang Ji, Sudhir Kumar, Jieping Ye, Zhi Hua Zhou

Research output: Chapter in Book/Report/Conference proceedingConference contribution

28 Scopus citations

Abstract

The Berkeley Drosophila Genome Project (BDGP) has produced a large number of gene expression patterns, many of which have been annotated textually with anatomical and developmental terms. These terms spatially correspond to local regions of the images; however, they are attached collectively to groups of images, such that it is unknown which term is assigned to which region of which image in the group. This poses a challenge to the development of the computational method to automate the textual description of expression patterns contained in each image. In this paper, we show that the underlying nature of this task matches well with a new machine learning framework,Multi-Instance Multi-Label learning (MIML). We propose a new MIML support vector machine to solve the problems that beset the annotation task. Empirical study shows that the proposed method outperforms the state-of-the-art Drosophila gene expression pattern annotation methods.

Original languageEnglish (US)
Title of host publicationIJCAI-09 - Proceedings of the 21st International Joint Conference on Artificial Intelligence
PublisherInternational Joint Conferences on Artificial Intelligence
Pages1445-1450
Number of pages6
ISBN (Print)9781577354260
StatePublished - Jan 1 2009
Event21st International Joint Conference on Artificial Intelligence, IJCAI 2009 - Pasadena, United States
Duration: Jul 11 2009Jul 16 2009

Publication series

NameIJCAI International Joint Conference on Artificial Intelligence
ISSN (Print)1045-0823

Conference

Conference21st International Joint Conference on Artificial Intelligence, IJCAI 2009
CountryUnited States
CityPasadena
Period7/11/097/16/09

ASJC Scopus subject areas

  • Artificial Intelligence

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  • Cite this

    Li, Y. X., Ji, S., Kumar, S., Ye, J., & Zhou, Z. H. (2009). Drosophila gene expression pattern annotation through multi-instance multi-label learning. In IJCAI-09 - Proceedings of the 21st International Joint Conference on Artificial Intelligence (pp. 1445-1450). (IJCAI International Joint Conference on Artificial Intelligence). International Joint Conferences on Artificial Intelligence.