Drive-selection equilibrium: Homopolymer evolution in the Drosophila gene mastermind

Stuart Newfeld, H. Tachida, B. Yedvobnick

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Interspecific sequence comparison of the highly repetitive Drosophila gene mastermind (mam) reveals extensive length variation in homopolymer domains. The length variation in homopolymers is due to nucleotide misalignment in the underlying triplet repeats, which can lead to slippage mutations during DNA replication or repair. In mam, the length variation in repetitive regions appears to be balanced by natural selection acting to maintain the distance between two highly conserved charge clusters. Here we report a statistical test of the null hypothesis that the similarity in the amino acid distance between the charge clusters of each species arose by chance. The results suggest that at mam there is a juxtaposition of length variability due to molecular drive and length conservation maintained by natural selection. The analysis of mam allows the extension of current theories of drive-selection interaction to encompass homopolymers. Our model of drive-selection equilibrium suggests that the physical flexibility, length variability, and abundance of homopolymer domains provide an important source of genetic variation for natural populations.

Original languageEnglish (US)
Pages (from-to)637-641
Number of pages5
JournalJournal of Molecular Evolution
Volume38
Issue number6
StatePublished - 1994
Externally publishedYes

Fingerprint

Genetic Selection
Homopolymerization
natural selection
Drosophila
Genes
Trinucleotide Repeats
gene
Nucleic Acid Repetitive Sequences
DNA Replication
DNA Repair
repair
genetic variation
mutation
genes
Nucleotides
amino acid
Amino Acids
DNA
Mutation
Statistical tests

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Agricultural and Biological Sciences (miscellaneous)
  • Ecology, Evolution, Behavior and Systematics
  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Genetics
  • Molecular Biology
  • Genetics(clinical)

Cite this

Drive-selection equilibrium : Homopolymer evolution in the Drosophila gene mastermind. / Newfeld, Stuart; Tachida, H.; Yedvobnick, B.

In: Journal of Molecular Evolution, Vol. 38, No. 6, 1994, p. 637-641.

Research output: Contribution to journalArticle

@article{b354fa6e6c1747f7a95e23272eb69edd,
title = "Drive-selection equilibrium: Homopolymer evolution in the Drosophila gene mastermind",
abstract = "Interspecific sequence comparison of the highly repetitive Drosophila gene mastermind (mam) reveals extensive length variation in homopolymer domains. The length variation in homopolymers is due to nucleotide misalignment in the underlying triplet repeats, which can lead to slippage mutations during DNA replication or repair. In mam, the length variation in repetitive regions appears to be balanced by natural selection acting to maintain the distance between two highly conserved charge clusters. Here we report a statistical test of the null hypothesis that the similarity in the amino acid distance between the charge clusters of each species arose by chance. The results suggest that at mam there is a juxtaposition of length variability due to molecular drive and length conservation maintained by natural selection. The analysis of mam allows the extension of current theories of drive-selection interaction to encompass homopolymers. Our model of drive-selection equilibrium suggests that the physical flexibility, length variability, and abundance of homopolymer domains provide an important source of genetic variation for natural populations.",
author = "Stuart Newfeld and H. Tachida and B. Yedvobnick",
year = "1994",
language = "English (US)",
volume = "38",
pages = "637--641",
journal = "Journal of Molecular Evolution",
issn = "0022-2844",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - Drive-selection equilibrium

T2 - Homopolymer evolution in the Drosophila gene mastermind

AU - Newfeld, Stuart

AU - Tachida, H.

AU - Yedvobnick, B.

PY - 1994

Y1 - 1994

N2 - Interspecific sequence comparison of the highly repetitive Drosophila gene mastermind (mam) reveals extensive length variation in homopolymer domains. The length variation in homopolymers is due to nucleotide misalignment in the underlying triplet repeats, which can lead to slippage mutations during DNA replication or repair. In mam, the length variation in repetitive regions appears to be balanced by natural selection acting to maintain the distance between two highly conserved charge clusters. Here we report a statistical test of the null hypothesis that the similarity in the amino acid distance between the charge clusters of each species arose by chance. The results suggest that at mam there is a juxtaposition of length variability due to molecular drive and length conservation maintained by natural selection. The analysis of mam allows the extension of current theories of drive-selection interaction to encompass homopolymers. Our model of drive-selection equilibrium suggests that the physical flexibility, length variability, and abundance of homopolymer domains provide an important source of genetic variation for natural populations.

AB - Interspecific sequence comparison of the highly repetitive Drosophila gene mastermind (mam) reveals extensive length variation in homopolymer domains. The length variation in homopolymers is due to nucleotide misalignment in the underlying triplet repeats, which can lead to slippage mutations during DNA replication or repair. In mam, the length variation in repetitive regions appears to be balanced by natural selection acting to maintain the distance between two highly conserved charge clusters. Here we report a statistical test of the null hypothesis that the similarity in the amino acid distance between the charge clusters of each species arose by chance. The results suggest that at mam there is a juxtaposition of length variability due to molecular drive and length conservation maintained by natural selection. The analysis of mam allows the extension of current theories of drive-selection interaction to encompass homopolymers. Our model of drive-selection equilibrium suggests that the physical flexibility, length variability, and abundance of homopolymer domains provide an important source of genetic variation for natural populations.

UR - http://www.scopus.com/inward/record.url?scp=0028364366&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028364366&partnerID=8YFLogxK

M3 - Article

C2 - 8083889

AN - SCOPUS:0028364366

VL - 38

SP - 637

EP - 641

JO - Journal of Molecular Evolution

JF - Journal of Molecular Evolution

SN - 0022-2844

IS - 6

ER -