Drive-selection equilibrium: Homopolymer evolution in the Drosophila gene mastermind

Stuart J. Newfeld, Hidenori Tachida, Barry Yedvobnick

Research output: Contribution to journalLetterpeer-review

15 Scopus citations

Abstract

Interspecific sequence comparison of the highly repetitive Drosophila gene mastermind (mam) reveals extensive length variation in homopolymer domains. The length variation in homopolymers is due to nucleotide misalignment in the underlying triplet repeats, which can lead to slippage mutations during DNA replication or repair. In mam, the length variation in repetitive regions appears to be balanced by natural selection acting to maintain the distance between two highly conserved charge clusters. Here we report a statistical test of the null hypothesis that the similarity in the amino acid distance between the charge clusters of each species arose by chance. The results suggest that at mam there is a juxtaposition of length variability due to molecular drive and length conservation maintained by natural selection. The analysis of mam allows the extension of current theories of drive-selection interaction to encompass homopolymers. Our model of drive-selection equilibrium suggests that the physical flexibility, length variability, and abundance of homopolymer domains provide an important source of genetic variation for natural populations.

Original languageEnglish (US)
Pages (from-to)637-641
Number of pages5
JournalJournal of Molecular Evolution
Volume38
Issue number6
DOIs
StatePublished - Jun 1994
Externally publishedYes

Keywords

  • Drosophila
  • Homopolymer
  • Molecular drive
  • Natural selection
  • Repeat length variation
  • mastermind

ASJC Scopus subject areas

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

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