Abstract

Experimental evidence suggests the existence of a negative feedback pathway between horizontal cells and cone photoreceptors in the outer plexiform layer of the retina that modulates the flow of calcium ions into the synaptic terminals of cones. However, the underlying mechanism for this feedback is controversial and there are currently three competing hypotheses: the ephaptic hypothesis, the pH hypothesis, and the GABA hypothesis. The goal of this investigation is to demonstrate the ephaptic hypothesis by means of detailed numerical simulations. The drift-diffusion (Poisson-Nernst-Planck) model with membrane boundary current equations is applied to a realistic two-dimensional cross-section of the triad synapse in the goldfish retina to verify the existence of strictly electrical feedback, as predicted by the ephaptic hypothesis. The effect on electrical feedback from the behavior of the bipolar cell membrane potential is also explored. The computed steady-state cone calcium transmembrane current-voltage curves for several cases are presented and compared with experimental data on goldfish. The results provide convincing evidence that an ephaptic mechanism can produce the feedback effect seen in experiments. The model and numerical methods presented here can be applied to any neuronal circuit where dendritic spines are invaginated in presynaptic terminals or boutons.

Original languageEnglish (US)
Pages (from-to)129-142
Number of pages14
JournalJournal of Computational Neuroscience
Volume38
Issue number1
DOIs
StatePublished - 2015

Fingerprint

Synapses
Retina
Goldfish
Presynaptic Terminals
Calcium
Retinal Cone Photoreceptor Cells
Dendritic Spines
Membrane Potentials
gamma-Aminobutyric Acid
Cell Membrane
Ions
Membranes

Keywords

  • Drift-diffusion model
  • Ephaptic effect
  • Retina
  • Synapse

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Cognitive Neuroscience
  • Sensory Systems

Cite this

Drift-diffusion simulation of the ephaptic effect in the triad synapse of the retina. / Gardner, Carl; Jones, Jeremiah R.; Baer, Steven; Crook, Sharon.

In: Journal of Computational Neuroscience, Vol. 38, No. 1, 2015, p. 129-142.

Research output: Contribution to journalArticle

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