Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents

Patrick G. Holder, Daniel T. Finley, Nicholas Stephanopoulos, Ross Walton, Douglas S. Clark, Matthew B. Francis

Research output: Contribution to journalArticle

31 Scopus citations


We have developed a method for integrating the self-assembling tobacco mosaic virus capsid into hydrophobic solvents and hydrophobic polymers. The capsid was modified at tyrosine residues to display an array of linear poly(ethylene glycol) chains, allowing it to be transferred into chloroform. In a subsequent step, the capsids could be transferred to a variety of hydrophobic solvents, including benzyl alcohol, o-dichlorobenzene, and diglyme. The thermal stability of the material against denaturation increased from 70 °C in water to at least 160 °C in hydrophobic solvents. With a view toward material fabrication, the polymer-coated TMV rods were also incorporated into solid polystyrene and thermally cast at 110 °C. Overall, this process significantly expands the range of processing conditions for TMV-based materials, with the goal of incorporating these templated nanoscale systems into conductive polymer matrices.

Original languageEnglish (US)
Pages (from-to)17383-17388
Number of pages6
Issue number22
StatePublished - Nov 16 2010
Externally publishedYes


ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Holder, P. G., Finley, D. T., Stephanopoulos, N., Walton, R., Clark, D. S., & Francis, M. B. (2010). Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. Langmuir, 26(22), 17383-17388. https://doi.org/10.1021/la1039305