Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents

Patrick G. Holder, Daniel T. Finley, Nicholas Stephanopoulos, Ross Walton, Douglas S. Clark, Matthew B. Francis

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

We have developed a method for integrating the self-assembling tobacco mosaic virus capsid into hydrophobic solvents and hydrophobic polymers. The capsid was modified at tyrosine residues to display an array of linear poly(ethylene glycol) chains, allowing it to be transferred into chloroform. In a subsequent step, the capsids could be transferred to a variety of hydrophobic solvents, including benzyl alcohol, o-dichlorobenzene, and diglyme. The thermal stability of the material against denaturation increased from 70 °C in water to at least 160 °C in hydrophobic solvents. With a view toward material fabrication, the polymer-coated TMV rods were also incorporated into solid polystyrene and thermally cast at 110 °C. Overall, this process significantly expands the range of processing conditions for TMV-based materials, with the goal of incorporating these templated nanoscale systems into conductive polymer matrices.

Original languageEnglish (US)
Pages (from-to)17383-17388
Number of pages6
JournalLangmuir
Volume26
Issue number22
DOIs
StatePublished - Nov 16 2010
Externally publishedYes

Fingerprint

viruses
Viruses
Polymers
Thermodynamic stability
thermal stability
polymers
Benzyl Alcohol
tobacco
Denaturation
Tobacco
biopolymer denaturation
tyrosine
Polystyrenes
Chloroform
Chlorine compounds
assembling
chloroform
Polymer matrix
Polyethylene glycols
Tyrosine

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Holder, P. G., Finley, D. T., Stephanopoulos, N., Walton, R., Clark, D. S., & Francis, M. B. (2010). Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. Langmuir, 26(22), 17383-17388. https://doi.org/10.1021/la1039305

Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. / Holder, Patrick G.; Finley, Daniel T.; Stephanopoulos, Nicholas; Walton, Ross; Clark, Douglas S.; Francis, Matthew B.

In: Langmuir, Vol. 26, No. 22, 16.11.2010, p. 17383-17388.

Research output: Contribution to journalArticle

Holder, PG, Finley, DT, Stephanopoulos, N, Walton, R, Clark, DS & Francis, MB 2010, 'Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents', Langmuir, vol. 26, no. 22, pp. 17383-17388. https://doi.org/10.1021/la1039305
Holder, Patrick G. ; Finley, Daniel T. ; Stephanopoulos, Nicholas ; Walton, Ross ; Clark, Douglas S. ; Francis, Matthew B. / Dramatic thermal stability of virus-polymer conjugates in hydrophobic solvents. In: Langmuir. 2010 ; Vol. 26, No. 22. pp. 17383-17388.
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