Downregulation of the immune system in low-quality child care: The case of Secretory Immunoglobulin A (SIgA) in toddlers

Harriet J. Vermeer, Marinus H. van IJzendoorn, Marleen G. Groeneveld, Douglas A. Granger

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Does the experience of stress during child care lead to downregulation of the immune system, in particular in low-quality care? Saliva was collected from 68 toddlers attending center or family child care at home and at child care, and assayed for secretory IgA (SIgA). Caregiver sensitivity was used as an index of quality of care and was observed during three videotaped episodes of 10. min. Diurnal patterns of SIgA showed a steep fall in the morning followed by a flattening out. SIgA was not associated with type of care, but lower caregiver sensitivity was associated with lower SIgA levels in both types of care. Quality of child care is associated with a non-specific secretory component of children's mucosal immunity with well established protective effects against upper respiratory infections.

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalPhysiology and Behavior
Volume105
Issue number2
DOIs
StatePublished - Jan 18 2012
Externally publishedYes

Fingerprint

Secretory Immunoglobulin A
Quality of Health Care
Child Care
Immune System
Down-Regulation
Caregivers
Secretory Component
Mucosal Immunity
Saliva
Respiratory Tract Infections
Toddlers

Keywords

  • Child care
  • Quality of care
  • Secretory Immunoglobulin A
  • SIgA
  • Toddlers

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Experimental and Cognitive Psychology
  • Philosophy

Cite this

Downregulation of the immune system in low-quality child care : The case of Secretory Immunoglobulin A (SIgA) in toddlers. / Vermeer, Harriet J.; van IJzendoorn, Marinus H.; Groeneveld, Marleen G.; Granger, Douglas A.

In: Physiology and Behavior, Vol. 105, No. 2, 18.01.2012, p. 161-167.

Research output: Contribution to journalArticle

Vermeer, Harriet J. ; van IJzendoorn, Marinus H. ; Groeneveld, Marleen G. ; Granger, Douglas A. / Downregulation of the immune system in low-quality child care : The case of Secretory Immunoglobulin A (SIgA) in toddlers. In: Physiology and Behavior. 2012 ; Vol. 105, No. 2. pp. 161-167.
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