Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits

Heng Wang; Li Peng Zhou; Yu Zheng; Kun Wang; Bo Song; Xuzhou Yan; Lukasz Wojtas; Xu Qing Wang; Xin Jiang; Ming Wang; Qing Fu Sun; Bingqian Xu; Hai Bo Yang; Andrew C.H. Sue; Yi Tsu Chan; Jonathan L. Sessler; Yang Jiao; Peter J. Stang; Xiaopeng Li

doi:10.1002/anie.202010805

Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits

Heng Wang, Li Peng Zhou, Yu Zheng, Kun Wang, Bo Song, Xuzhou Yan, Lukasz Wojtas, Xu Qing Wang, Xin Jiang, Ming Wang, Qing Fu Sun, Bingqian Xu, Hai Bo Yang, Andrew C.H. Sue, Yi Tsu Chan, Jonathan L. Sessler, Yang Jiao, Peter J. Stang, Xiaopeng Li

Engineering, Ira A. Fulton Schools of (IAFSE)

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Supramolecular cages/vesicles in biology display sophisticated structures and functions by utilizing a few types of protein subunit quasi-equivalently at distinct geometrical locations. However, synthetic supramolecular cages still lack comparable complexity to reach the high levels of functionality found in natural systems. Herein we report the self-assembly of giant pentagonal supramolecular prisms (molecular weight >50 kDa) with tetratopic pyridinyl subunits serving different geometrical roles within the structures, and their packing into a novel superstructure with unexpected three-fold rotational symmetry in a single two-dimensional layer of crystalline state. The formation of these complicated structures is controlled by both the predetermined angles of the ligands and the mismatched structural tensions created from the multi-layered geometry of the building blocks. Such a self-assembly strategy is extensively used by viruses to increase the volume and complexity of capsids and would provide a new approach to construct highly sophisticated supramolecular architectures.

Original language	English (US)
Pages (from-to)	1298-1305
Number of pages	8
Journal	Angewandte Chemie - International Edition
Volume	60
Issue number	3
DOIs	https://doi.org/10.1002/anie.202010805
State	Published - Jan 18 2021

Keywords

geometrically non-equivalent subunits
pentagonal packing
self-assembly
supramolecular prisms

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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10.1002/anie.202010805

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Wang, H., Zhou, L. P., Zheng, Y., Wang, K., Song, B., Yan, X., Wojtas, L., Wang, X. Q., Jiang, X., Wang, M., Sun, Q. F., Xu, B., Yang, H. B., Sue, A. C. H., Chan, Y. T., Sessler, J. L., Jiao, Y., Stang, P. J., & Li, X. (2021). Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits. Angewandte Chemie - International Edition, 60(3), 1298-1305. https://doi.org/10.1002/anie.202010805

Wang, H, Zhou, LP, Zheng, Y, Wang, K, Song, B, Yan, X, Wojtas, L, Wang, XQ, Jiang, X, Wang, M, Sun, QF, Xu, B, Yang, HB, Sue, ACH, Chan, YT, Sessler, JL, Jiao, Y, Stang, PJ & Li, X 2021, 'Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits', Angewandte Chemie - International Edition, vol. 60, no. 3, pp. 1298-1305. https://doi.org/10.1002/anie.202010805

@article{fc789eec135c402eaf00967c997dfdf3,

title = "Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits",

abstract = "Supramolecular cages/vesicles in biology display sophisticated structures and functions by utilizing a few types of protein subunit quasi-equivalently at distinct geometrical locations. However, synthetic supramolecular cages still lack comparable complexity to reach the high levels of functionality found in natural systems. Herein we report the self-assembly of giant pentagonal supramolecular prisms (molecular weight >50 kDa) with tetratopic pyridinyl subunits serving different geometrical roles within the structures, and their packing into a novel superstructure with unexpected three-fold rotational symmetry in a single two-dimensional layer of crystalline state. The formation of these complicated structures is controlled by both the predetermined angles of the ligands and the mismatched structural tensions created from the multi-layered geometry of the building blocks. Such a self-assembly strategy is extensively used by viruses to increase the volume and complexity of capsids and would provide a new approach to construct highly sophisticated supramolecular architectures.",

keywords = "geometrically non-equivalent subunits, pentagonal packing, self-assembly, supramolecular prisms",

author = "Heng Wang and Zhou, {Li Peng} and Yu Zheng and Kun Wang and Bo Song and Xuzhou Yan and Lukasz Wojtas and Wang, {Xu Qing} and Xin Jiang and Ming Wang and Sun, {Qing Fu} and Bingqian Xu and Yang, {Hai Bo} and Sue, {Andrew C.H.} and Chan, {Yi Tsu} and Sessler, {Jonathan L.} and Yang Jiao and Stang, {Peter J.} and Xiaopeng Li",

note = "Funding Information: We acknowledged both the Argonne National Laboratory (Advanced Photon Source, Beamline 15‐ID‐B of ChemMatCARS) and the Shanghai Synchrotron Radiation Facility (BL17B) for the synchrotron X‐ray diffraction analyses. The beamline and PILATUS3 X CdTe 1M detector are principally supported by NSF (CHE‐1346572 and DMR‐1531283). The use of the Advanced Photon Source, Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, is supported by the U.S. DOE (DE‐AC02‐06CH11357) X.L. acknowledges the support from Tencent Funders Alumni foundation. Funding Information: We acknowledged both the Argonne National Laboratory (Advanced Photon Source, Beamline 15-ID-B of ChemMatCARS) and the Shanghai Synchrotron Radiation Facility (BL17B) for the synchrotron X-ray diffraction analyses. The beamline and PILATUS3 X CdTe 1M detector are principally supported by NSF (CHE-1346572 and DMR-1531283). The use of the Advanced Photon Source, Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, is supported by the U.S. DOE (DE-AC02-06CH11357) X.L. acknowledges the support from Tencent Funders Alumni foundation. Publisher Copyright: {\textcopyright} 2020 Wiley-VCH GmbH",

year = "2021",

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doi = "10.1002/anie.202010805",

language = "English (US)",

volume = "60",

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T1 - Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits

AU - Wang, Heng

AU - Zhou, Li Peng

AU - Zheng, Yu

AU - Wang, Kun

AU - Song, Bo

AU - Yan, Xuzhou

AU - Wojtas, Lukasz

AU - Wang, Xu Qing

AU - Jiang, Xin

AU - Wang, Ming

AU - Sun, Qing Fu

AU - Xu, Bingqian

AU - Yang, Hai Bo

AU - Sue, Andrew C.H.

AU - Chan, Yi Tsu

AU - Sessler, Jonathan L.

AU - Jiao, Yang

AU - Stang, Peter J.

AU - Li, Xiaopeng

N1 - Funding Information: We acknowledged both the Argonne National Laboratory (Advanced Photon Source, Beamline 15‐ID‐B of ChemMatCARS) and the Shanghai Synchrotron Radiation Facility (BL17B) for the synchrotron X‐ray diffraction analyses. The beamline and PILATUS3 X CdTe 1M detector are principally supported by NSF (CHE‐1346572 and DMR‐1531283). The use of the Advanced Photon Source, Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, is supported by the U.S. DOE (DE‐AC02‐06CH11357) X.L. acknowledges the support from Tencent Funders Alumni foundation. Funding Information: We acknowledged both the Argonne National Laboratory (Advanced Photon Source, Beamline 15-ID-B of ChemMatCARS) and the Shanghai Synchrotron Radiation Facility (BL17B) for the synchrotron X-ray diffraction analyses. The beamline and PILATUS3 X CdTe 1M detector are principally supported by NSF (CHE-1346572 and DMR-1531283). The use of the Advanced Photon Source, Office of Science User Facility operated for the U.S. Department of Energy (DOE) Office of Science by Argonne National Laboratory, is supported by the U.S. DOE (DE-AC02-06CH11357) X.L. acknowledges the support from Tencent Funders Alumni foundation. Publisher Copyright: © 2020 Wiley-VCH GmbH

PY - 2021/1/18

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N2 - Supramolecular cages/vesicles in biology display sophisticated structures and functions by utilizing a few types of protein subunit quasi-equivalently at distinct geometrical locations. However, synthetic supramolecular cages still lack comparable complexity to reach the high levels of functionality found in natural systems. Herein we report the self-assembly of giant pentagonal supramolecular prisms (molecular weight >50 kDa) with tetratopic pyridinyl subunits serving different geometrical roles within the structures, and their packing into a novel superstructure with unexpected three-fold rotational symmetry in a single two-dimensional layer of crystalline state. The formation of these complicated structures is controlled by both the predetermined angles of the ligands and the mismatched structural tensions created from the multi-layered geometry of the building blocks. Such a self-assembly strategy is extensively used by viruses to increase the volume and complexity of capsids and would provide a new approach to construct highly sophisticated supramolecular architectures.

AB - Supramolecular cages/vesicles in biology display sophisticated structures and functions by utilizing a few types of protein subunit quasi-equivalently at distinct geometrical locations. However, synthetic supramolecular cages still lack comparable complexity to reach the high levels of functionality found in natural systems. Herein we report the self-assembly of giant pentagonal supramolecular prisms (molecular weight >50 kDa) with tetratopic pyridinyl subunits serving different geometrical roles within the structures, and their packing into a novel superstructure with unexpected three-fold rotational symmetry in a single two-dimensional layer of crystalline state. The formation of these complicated structures is controlled by both the predetermined angles of the ligands and the mismatched structural tensions created from the multi-layered geometry of the building blocks. Such a self-assembly strategy is extensively used by viruses to increase the volume and complexity of capsids and would provide a new approach to construct highly sophisticated supramolecular architectures.

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KW - pentagonal packing

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Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits

Abstract

Keywords

ASJC Scopus subject areas

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CCDC 1998124: Experimental Crystal Structure Determination

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Double-Layered Supramolecular Prisms Self-Assembled by Geometrically Non-equivalent Tetratopic Subunits

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

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CCDC 1998124: Experimental Crystal Structure Determination

Cite this