Dose and host characteristics influence virulence of ranavirus infections

Jesse L. Brunner, Kathryn Richards, James Collins

Research output: Contribution to journalArticle

76 Citations (Scopus)

Abstract

Parasites play a prominent role in the ecology, evolution, and more recently, conservation of many organisms. For example, emerging infectious diseases, including a group of lethal ranaviruses, are associated with the declines and extinctions of amphibians around the world. An increasingly important basic and applied question is: what controls parasite virulence? We used a dose-response experiment with three laboratory-bred clutches of tiger salamander larvae (Ambystoma tigrinum) to test how the size of inoculum and host genetic factors influence the dynamics and outcome of ranavirus infections. We found that infection rates increased with dose and were strongly affected by clutch identity and host life history stage. Case mortality increased with dose of inoculum, but was unaffected by host characteristics. Average survival time decreased with dose and differed among clutches, but this was largely due to differences in the time to onset of symptoms. Overall, our results suggest that dose of inoculum and host characteristics (life history stage and genetic background) influence the establishment and early virus replication, and therefore the virulence of ranavirus infections.

Original languageEnglish (US)
Pages (from-to)399-406
Number of pages8
JournalOecologia
Volume144
Issue number3
DOIs
StatePublished - Jul 2005

Fingerprint

Ranavirus
virulence
inoculum
dosage
infection
life history
Ambystoma tigrinum
parasites
parasite control
Ambystoma
emerging diseases
virus replication
genetic background
signs and symptoms (animals and humans)
dose response
amphibians
infectious disease
extinction
amphibian
breeds

Keywords

  • Dose effects
  • Life history stage
  • Ranavirus
  • Tiger salamander
  • Virulence

ASJC Scopus subject areas

  • Ecology

Cite this

Dose and host characteristics influence virulence of ranavirus infections. / Brunner, Jesse L.; Richards, Kathryn; Collins, James.

In: Oecologia, Vol. 144, No. 3, 07.2005, p. 399-406.

Research output: Contribution to journalArticle

Brunner, Jesse L. ; Richards, Kathryn ; Collins, James. / Dose and host characteristics influence virulence of ranavirus infections. In: Oecologia. 2005 ; Vol. 144, No. 3. pp. 399-406.
@article{841a05d2ddc24778b3f9eb800e7d3be9,
title = "Dose and host characteristics influence virulence of ranavirus infections",
abstract = "Parasites play a prominent role in the ecology, evolution, and more recently, conservation of many organisms. For example, emerging infectious diseases, including a group of lethal ranaviruses, are associated with the declines and extinctions of amphibians around the world. An increasingly important basic and applied question is: what controls parasite virulence? We used a dose-response experiment with three laboratory-bred clutches of tiger salamander larvae (Ambystoma tigrinum) to test how the size of inoculum and host genetic factors influence the dynamics and outcome of ranavirus infections. We found that infection rates increased with dose and were strongly affected by clutch identity and host life history stage. Case mortality increased with dose of inoculum, but was unaffected by host characteristics. Average survival time decreased with dose and differed among clutches, but this was largely due to differences in the time to onset of symptoms. Overall, our results suggest that dose of inoculum and host characteristics (life history stage and genetic background) influence the establishment and early virus replication, and therefore the virulence of ranavirus infections.",
keywords = "Dose effects, Life history stage, Ranavirus, Tiger salamander, Virulence",
author = "Brunner, {Jesse L.} and Kathryn Richards and James Collins",
year = "2005",
month = "7",
doi = "10.1007/s00442-005-0093-5",
language = "English (US)",
volume = "144",
pages = "399--406",
journal = "Oecologia",
issn = "0029-8519",
publisher = "Springer Verlag",
number = "3",

}

TY - JOUR

T1 - Dose and host characteristics influence virulence of ranavirus infections

AU - Brunner, Jesse L.

AU - Richards, Kathryn

AU - Collins, James

PY - 2005/7

Y1 - 2005/7

N2 - Parasites play a prominent role in the ecology, evolution, and more recently, conservation of many organisms. For example, emerging infectious diseases, including a group of lethal ranaviruses, are associated with the declines and extinctions of amphibians around the world. An increasingly important basic and applied question is: what controls parasite virulence? We used a dose-response experiment with three laboratory-bred clutches of tiger salamander larvae (Ambystoma tigrinum) to test how the size of inoculum and host genetic factors influence the dynamics and outcome of ranavirus infections. We found that infection rates increased with dose and were strongly affected by clutch identity and host life history stage. Case mortality increased with dose of inoculum, but was unaffected by host characteristics. Average survival time decreased with dose and differed among clutches, but this was largely due to differences in the time to onset of symptoms. Overall, our results suggest that dose of inoculum and host characteristics (life history stage and genetic background) influence the establishment and early virus replication, and therefore the virulence of ranavirus infections.

AB - Parasites play a prominent role in the ecology, evolution, and more recently, conservation of many organisms. For example, emerging infectious diseases, including a group of lethal ranaviruses, are associated with the declines and extinctions of amphibians around the world. An increasingly important basic and applied question is: what controls parasite virulence? We used a dose-response experiment with three laboratory-bred clutches of tiger salamander larvae (Ambystoma tigrinum) to test how the size of inoculum and host genetic factors influence the dynamics and outcome of ranavirus infections. We found that infection rates increased with dose and were strongly affected by clutch identity and host life history stage. Case mortality increased with dose of inoculum, but was unaffected by host characteristics. Average survival time decreased with dose and differed among clutches, but this was largely due to differences in the time to onset of symptoms. Overall, our results suggest that dose of inoculum and host characteristics (life history stage and genetic background) influence the establishment and early virus replication, and therefore the virulence of ranavirus infections.

KW - Dose effects

KW - Life history stage

KW - Ranavirus

KW - Tiger salamander

KW - Virulence

UR - http://www.scopus.com/inward/record.url?scp=25844471146&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=25844471146&partnerID=8YFLogxK

U2 - 10.1007/s00442-005-0093-5

DO - 10.1007/s00442-005-0093-5

M3 - Article

C2 - 15891818

AN - SCOPUS:25844471146

VL - 144

SP - 399

EP - 406

JO - Oecologia

JF - Oecologia

SN - 0029-8519

IS - 3

ER -