Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

Robert B. Bates; Kennard G. Brusoe; Jennifer J. Burns; Sriyani Caldera; Wei Cui; Sanjeev Gangwar; Michelle R. Gramme; Kelly J. McClure; Gregory P. Rouen; Heiko Schadow; Chad C. Stessman; Stuart R. Taylor; Vicky H. Vu; Gayle V. Yarick; Jianxing Zhang; George R. Pettit; Roger Bontems

doi:10.1021/ja963857y

Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

Robert B. Bates, Kennard G. Brusoe, Jennifer J. Burns, Sriyani Caldera, Wei Cui, Sanjeev Gangwar, Michelle R. Gramme, Kelly J. McClure, Gregory P. Rouen, Heiko Schadow, Chad C. Stessman, Stuart R. Taylor, Vicky H. Vu, Gayle V. Yarick, Jianxing Zhang, George R. Pettit, Roger Bontems

Molecular Sciences, School of (SMS)

Research output: Contribution to journal › Article › peer-review

51 Scopus citations

Abstract

The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.

Original language	English (US)
Pages (from-to)	2111-2113
Number of pages	3
Journal	Journal of the American Chemical Society
Volume	119
Issue number	9
DOIs	https://doi.org/10.1021/ja963857y
State	Published - 1997

ASJC Scopus subject areas

Catalysis
General Chemistry
Biochemistry
Colloid and Surface Chemistry

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Bates, R. B., Brusoe, K. G., Burns, J. J., Caldera, S., Cui, W., Gangwar, S., Gramme, M. R., McClure, K. J., Rouen, G. P., Schadow, H., Stessman, C. C., Taylor, S. R., Vu, V. H., Yarick, G. V., Zhang, J., Pettit, G. R., & Bontems, R. (1997). Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11. Journal of the American Chemical Society, 119(9), 2111-2113. https://doi.org/10.1021/ja963857y

Bates, RB, Brusoe, KG, Burns, JJ, Caldera, S, Cui, W, Gangwar, S, Gramme, MR, McClure, KJ, Rouen, GP, Schadow, H, Stessman, CC, Taylor, SR, Vu, VH, Yarick, GV, Zhang, J, Pettit, GR & Bontems, R 1997, 'Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11', Journal of the American Chemical Society, vol. 119, no. 9, pp. 2111-2113. https://doi.org/10.1021/ja963857y

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abstract = "The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.",

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doi = "10.1021/ja963857y",

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AU - Cui, Wei

AU - Gangwar, Sanjeev

AU - Gramme, Michelle R.

AU - McClure, Kelly J.

AU - Rouen, Gregory P.

AU - Schadow, Heiko

AU - Stessman, Chad C.

AU - Taylor, Stuart R.

AU - Vu, Vicky H.

AU - Yarick, Gayle V.

AU - Zhang, Jianxing

AU - Pettit, George R.

AU - Bontems, Roger

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AB - The first synthesis of dolastatin 11, a potent antineoplastic agent from the sea hare Dolabella auricularia, confirmed the proposed structure and established the last configuration in this natural product and in dolastatin 12, majusculamide C, and 57-normajusculamide C.

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Dolastatins. 26. Synthesis and stereochemistry of dolastatin 11

Abstract

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