TY - JOUR
T1 - Dolastatins 24. Synthesis of (-)-dolastatin 10. X-Ray molecular structure of N,N-dimethylvalyl-valyl-dolaisoleuine tert-butyl ester
AU - Pettit, George
AU - Srirangam, Jayaram K.
AU - Singh, Sheo Bux
AU - Williams, Michael D.
AU - Herald, Delbert L.
AU - Barkóczy, József
AU - Kantoci, Darko
AU - Hogan, Fiona
PY - 1996/4/21
Y1 - 1996/4/21
N2 - Total synthesis of the extraordinary antineoplastic constituent, dolastatin 10, from the Indian Ocean mollusc Dolabella auricularia has been summarized. The final synthetic step involved diethyl cyanophosphonate-mediated coupling of Dov-Val-Dil with Dap-Doe. Improved syntheses of these important precursors has led to a very practical synthesis of natural dolastatin 10. Important details of the HPLC and high-field (500 MHz) NMR characterization techniques employed to confirm the purity of dolastatin 10 have been recorded.
AB - Total synthesis of the extraordinary antineoplastic constituent, dolastatin 10, from the Indian Ocean mollusc Dolabella auricularia has been summarized. The final synthetic step involved diethyl cyanophosphonate-mediated coupling of Dov-Val-Dil with Dap-Doe. Improved syntheses of these important precursors has led to a very practical synthesis of natural dolastatin 10. Important details of the HPLC and high-field (500 MHz) NMR characterization techniques employed to confirm the purity of dolastatin 10 have been recorded.
UR - http://www.scopus.com/inward/record.url?scp=0002531417&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0002531417&partnerID=8YFLogxK
U2 - 10.1039/P19960000859
DO - 10.1039/P19960000859
M3 - Article
AN - SCOPUS:0002531417
SN - 1470-4358
SP - 859
EP - 863
JO - Journal of the Chemical Society, Perkin Transactions 1
JF - Journal of the Chemical Society, Perkin Transactions 1
IS - 8
ER -