DNA-Templated Self-Assembly of Protein and Nanoparticle Linear Arrays

Hanying Li, Sung Ha Park, John H. Reif, Thomas H. LaBean, Hao Yan

Research output: Contribution to journalArticlepeer-review

287 Scopus citations


Self-assembling DNA tiling lattices represent a versatile system for nanoscale construction. Self-assembled DNA arrays provide an excellent template for spatially positioning other molecules with increased relative precision and programmability. Here we report an experiment using a linear array of DNA triple crossover tiles to controllably template the self-assembly of single-layer or double-layer linear arrays of streptavidin molecules and streptavidin-conjugated nanogold particles through biotin-streptavidin interaction. The organization of streptavidin and its conjugated gold nanoparticles into periodic arrays was visualized by atomic force microscopy and scanning electron microscopy.

Original languageEnglish (US)
Pages (from-to)418-419
Number of pages2
JournalJournal of the American Chemical Society
Issue number2
StatePublished - Jan 21 2004
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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