DNA polymorphism detector: An automated tool that searches for allelic matches in public databases for discrepancies found in clone or cDNA sequences

Chin Yu Chang, Joshua LaBaer

Research output: Contribution to journalArticle

2 Scopus citations

Abstract

Summary: DNA polymorphism detector (DPD) is a new web application developed to help automate the process of CDNA clone validation. DPD identifies and highlights discrepancies between any cDNA clone sequence and its expected reference sequence. To determine if these differences correspond to natural genetic polymorphisms (versus artifacts introduced during clone production or evaluation), DPD uses the discrepancies, along with flanking sequences, to search GenBank for identical matching strings. If matching DNA sequences are found, DPD verifies that they are from the same gene. The application then reports the discrepancy as a polymorphism along with the corresponding GenBank reference information.

Original languageEnglish (US)
Pages (from-to)2133-2135
Number of pages3
JournalBioinformatics
Volume21
Issue number9
DOIs
StatePublished - May 1 2005
Externally publishedYes

ASJC Scopus subject areas

  • Statistics and Probability
  • Biochemistry
  • Molecular Biology
  • Computer Science Applications
  • Computational Theory and Mathematics
  • Computational Mathematics

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