DNA polymerase β inhibitors from Sandoricum koetjape

Di An Sun, Shelley R. Starck, Edward P. Locke, Sidney M. Hecht

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase inhibition led to the isolation of three active compounds (1-3) having IC50 values from 20 to 36 μM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC50 values ranging from 16 to 36 μM.

Original languageEnglish (US)
Pages (from-to)1110-1113
Number of pages4
JournalJournal of Natural Products
Volume62
Issue number8
DOIs
StatePublished - Aug 1999

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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