DNA polymerase β inhibitors from Sandoricum koetjape

Di An Sun; Shelley R. Starck; Edward P. Locke; Sidney M. Hecht

doi:10.1021/np990104r

DNA polymerase β inhibitors from Sandoricum koetjape

Di An Sun, Shelley R. Starck, Edward P. Locke, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

40 Scopus citations

Abstract

Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase inhibition led to the isolation of three active compounds (1-3) having IC₅₀ values from 20 to 36 μM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC₅₀ values ranging from 16 to 36 μM.

Original language	English (US)
Pages (from-to)	1110-1113
Number of pages	4
Journal	Journal of Natural Products
Volume	62
Issue number	8
DOIs	https://doi.org/10.1021/np990104r
State	Published - Aug 1999
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

Access to Document

10.1021/np990104r

Cite this

@article{7c362718fd574f98a6275ff2bae3f2b6,

title = "DNA polymerase β inhibitors from Sandoricum koetjape",

abstract = "Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase inhibition led to the isolation of three active compounds (1-3) having IC50 values from 20 to 36 μM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC50 values ranging from 16 to 36 μM.",

author = "Sun, {Di An} and Starck, {Shelley R.} and Locke, {Edward P.} and Hecht, {Sidney M.}",

year = "1999",

month = aug,

doi = "10.1021/np990104r",

language = "English (US)",

volume = "62",

pages = "1110--1113",

journal = "Journal of Natural Products",

issn = "0163-3864",

publisher = "American Chemical Society",

number = "8",

}

TY - JOUR

T1 - DNA polymerase β inhibitors from Sandoricum koetjape

AU - Sun, Di An

AU - Starck, Shelley R.

AU - Locke, Edward P.

AU - Hecht, Sidney M.

PY - 1999/8

Y1 - 1999/8

N2 - Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase inhibition led to the isolation of three active compounds (1-3) having IC50 values from 20 to 36 μM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC50 values ranging from 16 to 36 μM.

AB - Bioassay-guided fractionation of Sandoricum koetjape using an assay sensitive to DNA polymerase inhibition led to the isolation of three active compounds (1-3) having IC50 values from 20 to 36 μM. Derivatives 5-14 were prepared from compounds 1 and 2; derivatives 11, 12, and 13 showed activity against DNA polymerase β with IC50 values ranging from 16 to 36 μM.

UR - http://www.scopus.com/inward/record.url?scp=0032822306&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032822306&partnerID=8YFLogxK

U2 - 10.1021/np990104r

DO - 10.1021/np990104r

M3 - Article

C2 - 10479314

AN - SCOPUS:0032822306

SN - 0163-3864

VL - 62

SP - 1110

EP - 1113

JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 8

ER -

DNA polymerase β inhibitors from Sandoricum koetjape

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this