DNA polyfluorophores for real-time multicolor tracking of dynamic biological systems

Shenliang Wang, Jia Guo, Toshikazu Ono, Eric T. Kool

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Dye-ing to live: Spectral limitations of common organic dyes make it difficult or impossible to visualize and follow multiple biological components in rapidly moving systems. The development of a multispectral set of improved DNA-scaffolded fluorophores is described. Their use in multicolor cellular imaging (see scheme) and in tracking of biological motions on the subsecond timescale is demonstrated.

Original languageEnglish (US)
Pages (from-to)7176-7180
Number of pages5
JournalAngewandte Chemie - International Edition
Volume51
Issue number29
DOIs
StatePublished - Jul 16 2012
Externally publishedYes

Keywords

  • Fluorescence
  • Imaging agents
  • Multicolor
  • Oligonucleotides
  • Real-time tracking

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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