Abstract
We present a strategy to design and construct self-assembling DNA nanostructures that define intricate curved surfaces in three-dimensional (3D) space using the DNA origami folding technique. Double-helical DNA is bent to follow the rounded contours of the target object, and potential strand crossovers are subsequently identified. Concentric rings of DNA are used to generate in-plane curvature, constrained to 2D by rationally designed geometries and crossover networks. Out-of-plane curvature is introduced by adjusting the particular position and pattern of crossovers between adjacent DNA double helices, whose conformation often deviates from the natural, B-form twist density. A series of DNA nanostructures with high curvature-such as 2D arrangements of concentric rings and 3D spherical shells, ellipsoidal shells, and a nanoflask-were assembled.
Original language | English (US) |
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Pages (from-to) | 342-346 |
Number of pages | 5 |
Journal | Science |
Volume | 332 |
Issue number | 6027 |
DOIs | |
State | Published - Apr 15 2011 |
ASJC Scopus subject areas
- General