TY - JOUR
T1 - DNA Origami
T2 - Scaffolds for Creating Higher Order Structures
AU - Hong, Fan
AU - Zhang, Fei
AU - Liu, Yan
AU - Yan, Hao
N1 - Funding Information:
This work was supported by grants from the Army Research Office, National Institute of Health, Office of Naval Research and National Science Foundation to H.Y. and Y.L.
Publisher Copyright:
© 2017 American Chemical Society.
PY - 2017/10/25
Y1 - 2017/10/25
N2 - DNA has become one of the most extensively used molecular building blocks for engineering self-assembling materials. DNA origami is a technique that uses hundreds of short DNA oligonucleotides, called staple strands, to fold a long single-stranded DNA, which is called a scaffold strand, into various designer nanoscale architectures. DNA origami has dramatically improved the complexity and scalability of DNA nanostructures. Due to its high degree of customization and spatial addressability, DNA origami provides a versatile platform with which to engineer nanoscale structures and devices that can sense, compute, and actuate. These capabilities open up opportunities for a broad range of applications in chemistry, biology, physics, material science, and computer science that have often required programmed spatial control of molecules and atoms in three-dimensional (3D) space. This review provides a comprehensive survey of recent developments in DNA origami structure, design, assembly, and directed self-assembly, as well as its broad applications.
AB - DNA has become one of the most extensively used molecular building blocks for engineering self-assembling materials. DNA origami is a technique that uses hundreds of short DNA oligonucleotides, called staple strands, to fold a long single-stranded DNA, which is called a scaffold strand, into various designer nanoscale architectures. DNA origami has dramatically improved the complexity and scalability of DNA nanostructures. Due to its high degree of customization and spatial addressability, DNA origami provides a versatile platform with which to engineer nanoscale structures and devices that can sense, compute, and actuate. These capabilities open up opportunities for a broad range of applications in chemistry, biology, physics, material science, and computer science that have often required programmed spatial control of molecules and atoms in three-dimensional (3D) space. This review provides a comprehensive survey of recent developments in DNA origami structure, design, assembly, and directed self-assembly, as well as its broad applications.
UR - http://www.scopus.com/inward/record.url?scp=85032282941&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85032282941&partnerID=8YFLogxK
U2 - 10.1021/acs.chemrev.6b00825
DO - 10.1021/acs.chemrev.6b00825
M3 - Article
C2 - 28605177
AN - SCOPUS:85032282941
SN - 0009-2665
VL - 117
SP - 12584
EP - 12640
JO - Chemical reviews
JF - Chemical reviews
IS - 20
ER -