Abstract
Engineering wireframe architectures and scaffolds of increasing complexity is one of the important challenges in nanotechnology. We present a design strategy to create gridiron-like DNA structures. A series of four-arm junctions are used as vertices within a network of double-helical DNA fragments. Deliberate distortion of the junctions from their most relaxed conformations ensures that a scaffold strand can traverse through individual vertices in multiple directions. DNA gridirons were assembled, ranging from two-dimensional arrays with reconfigurability to multilayer and three-dimensional structures and curved objects.
Original language | English (US) |
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Pages (from-to) | 1412-1415 |
Number of pages | 4 |
Journal | Science |
Volume | 339 |
Issue number | 6126 |
DOIs | |
State | Published - Mar 22 2013 |
ASJC Scopus subject areas
- General