DNA-damaging agents from Crypteronia paniculata

Jing Zhen Deng, Rebekah Marshall, Shannon H. Jones, Randall K. Johnson, Sidney M. Hecht

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

A survey of crude plant extracts using a new yeast strain designed to identify DNA-damaging agents resulted in the identification of an extract prepared from Crypteronia paniculata. Bioassay-guided fractionation resulted in the isolation of three active compounds. Two of these were ellagic acid derivatives, namely, 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (1) and 3′-O-methyl-3,4-methylenedioxyellagic acid 4′-O-β-D-glucopyranoside (2). The third was identified as kaempferol-3-O-α-L-rhamnoside (3). The three principles exhibited strong, selective cytotoxity toward the RAD52 repair-deficient yeast strain.

Original languageEnglish (US)
Pages (from-to)1930-1932
Number of pages3
JournalJournal of Natural Products
Volume65
Issue number12
DOIs
StatePublished - Dec 1 2002
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

Fingerprint Dive into the research topics of 'DNA-damaging agents from Crypteronia paniculata'. Together they form a unique fingerprint.

  • Cite this

    Deng, J. Z., Marshall, R., Jones, S. H., Johnson, R. K., & Hecht, S. M. (2002). DNA-damaging agents from Crypteronia paniculata. Journal of Natural Products, 65(12), 1930-1932. https://doi.org/10.1021/np020285o