DNA-damaging agents from Crypteronia paniculata

Jing Zhen Deng; Rebekah Marshall; Shannon H. Jones; Randall K. Johnson; Sidney M. Hecht

doi:10.1021/np020285o

DNA-damaging agents from Crypteronia paniculata

Jing Zhen Deng, Rebekah Marshall, Shannon H. Jones, Randall K. Johnson, Sidney M. Hecht

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

A survey of crude plant extracts using a new yeast strain designed to identify DNA-damaging agents resulted in the identification of an extract prepared from Crypteronia paniculata. Bioassay-guided fractionation resulted in the isolation of three active compounds. Two of these were ellagic acid derivatives, namely, 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (1) and 3′-O-methyl-3,4-methylenedioxyellagic acid 4′-O-β-D-glucopyranoside (2). The third was identified as kaempferol-3-O-α-L-rhamnoside (3). The three principles exhibited strong, selective cytotoxity toward the RAD52 repair-deficient yeast strain.

Original language	English (US)
Pages (from-to)	1930-1932
Number of pages	3
Journal	Journal of Natural Products
Volume	65
Issue number	12
DOIs	https://doi.org/10.1021/np020285o
State	Published - Dec 1 2002
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "DNA-damaging agents from Crypteronia paniculata",

abstract = "A survey of crude plant extracts using a new yeast strain designed to identify DNA-damaging agents resulted in the identification of an extract prepared from Crypteronia paniculata. Bioassay-guided fractionation resulted in the isolation of three active compounds. Two of these were ellagic acid derivatives, namely, 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (1) and 3′-O-methyl-3,4-methylenedioxyellagic acid 4′-O-β-D-glucopyranoside (2). The third was identified as kaempferol-3-O-α-L-rhamnoside (3). The three principles exhibited strong, selective cytotoxity toward the RAD52 repair-deficient yeast strain.",

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AU - Deng, Jing Zhen

AU - Marshall, Rebekah

AU - Jones, Shannon H.

AU - Johnson, Randall K.

AU - Hecht, Sidney M.

PY - 2002/12/1

Y1 - 2002/12/1

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AB - A survey of crude plant extracts using a new yeast strain designed to identify DNA-damaging agents resulted in the identification of an extract prepared from Crypteronia paniculata. Bioassay-guided fractionation resulted in the isolation of three active compounds. Two of these were ellagic acid derivatives, namely, 3,3′-di-O-methylellagic acid 4′-O-β-D-xylopyranoside (1) and 3′-O-methyl-3,4-methylenedioxyellagic acid 4′-O-β-D-glucopyranoside (2). The third was identified as kaempferol-3-O-α-L-rhamnoside (3). The three principles exhibited strong, selective cytotoxity toward the RAD52 repair-deficient yeast strain.

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DNA-damaging agents from Crypteronia paniculata

Abstract

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