DNA damaging activity of ellagic acid derivatives

Ya Ming Xu, Jing Zhen Deng, Ji Ma, Shao Nong Chen, Rebekah Marshall, Shannon H. Jones, Randall K. Johnson, Sidney M. Hecht

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

A strain of yeast rendered repair deficient by the conditional expression of the RAD52 locus was used to search for natural products capable of damaging DNA. Four ellagic acid derivatives, namely 3,3′-dimethyl-4′-O-β-D-glucopyranosyl ellagic acid (1), 3,3′,4-trimethyl-4′-O-β-D-glucopyranosyl ellagic acid (2), 3′-methyl-3,4-O,O-methylidene ellagic acid (3) and 3′-methyl-3,4-O,O-methylidene-4′-O-β-D-glucopyranosyl ellagic acid (4), were identified by this assay as DNA damaging natural principles from several plants, including Alangium javanicum, Anisophyllea apetala, Crypteronia paniculata, Mouririi sp. and Scholtzia parviflora. Although none of the isolated principles mediated frank strand scission of DNA in vitro, all of them potently inhibited the growth of yeast in the absence of expression of RAD52.

Original languageEnglish (US)
Pages (from-to)1593-1596
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number7
DOIs
StatePublished - Apr 1 2003
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Xu, Y. M., Deng, J. Z., Ma, J., Chen, S. N., Marshall, R., Jones, S. H., Johnson, R. K., & Hecht, S. M. (2003). DNA damaging activity of ellagic acid derivatives. Bioorganic and Medicinal Chemistry, 11(7), 1593-1596. https://doi.org/10.1016/S0968-0896(02)00452-2