DNA damaging activity of ellagic acid derivatives

Ya Ming Xu, Jing Zhen Deng, Ji Ma, Shao Nong Chen, Rebekah Marshall, Shannon H. Jones, Randall K. Johnson, Sidney Hecht

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

A strain of yeast rendered repair deficient by the conditional expression of the RAD52 locus was used to search for natural products capable of damaging DNA. Four ellagic acid derivatives, namely 3,3′-dimethyl-4′-O-β-D-glucopyranosyl ellagic acid (1), 3,3′,4-trimethyl-4′-O-β-D-glucopyranosyl ellagic acid (2), 3′-methyl-3,4-O,O-methylidene ellagic acid (3) and 3′-methyl-3,4-O,O-methylidene-4′-O-β-D-glucopyranosyl ellagic acid (4), were identified by this assay as DNA damaging natural principles from several plants, including Alangium javanicum, Anisophyllea apetala, Crypteronia paniculata, Mouririi sp. and Scholtzia parviflora. Although none of the isolated principles mediated frank strand scission of DNA in vitro, all of them potently inhibited the growth of yeast in the absence of expression of RAD52.

Original languageEnglish (US)
Pages (from-to)1593-1596
Number of pages4
JournalBioorganic and Medicinal Chemistry
Volume11
Issue number7
DOIs
StatePublished - Apr 2003
Externally publishedYes

Fingerprint

Ellagic Acid
Derivatives
DNA
Yeast
Alangiaceae
Yeasts
Biological Products
Assays
Repair
Growth

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

Cite this

Xu, Y. M., Deng, J. Z., Ma, J., Chen, S. N., Marshall, R., Jones, S. H., ... Hecht, S. (2003). DNA damaging activity of ellagic acid derivatives. Bioorganic and Medicinal Chemistry, 11(7), 1593-1596. https://doi.org/10.1016/S0968-0896(02)00452-2

DNA damaging activity of ellagic acid derivatives. / Xu, Ya Ming; Deng, Jing Zhen; Ma, Ji; Chen, Shao Nong; Marshall, Rebekah; Jones, Shannon H.; Johnson, Randall K.; Hecht, Sidney.

In: Bioorganic and Medicinal Chemistry, Vol. 11, No. 7, 04.2003, p. 1593-1596.

Research output: Contribution to journalArticle

Xu, YM, Deng, JZ, Ma, J, Chen, SN, Marshall, R, Jones, SH, Johnson, RK & Hecht, S 2003, 'DNA damaging activity of ellagic acid derivatives', Bioorganic and Medicinal Chemistry, vol. 11, no. 7, pp. 1593-1596. https://doi.org/10.1016/S0968-0896(02)00452-2
Xu YM, Deng JZ, Ma J, Chen SN, Marshall R, Jones SH et al. DNA damaging activity of ellagic acid derivatives. Bioorganic and Medicinal Chemistry. 2003 Apr;11(7):1593-1596. https://doi.org/10.1016/S0968-0896(02)00452-2
Xu, Ya Ming ; Deng, Jing Zhen ; Ma, Ji ; Chen, Shao Nong ; Marshall, Rebekah ; Jones, Shannon H. ; Johnson, Randall K. ; Hecht, Sidney. / DNA damaging activity of ellagic acid derivatives. In: Bioorganic and Medicinal Chemistry. 2003 ; Vol. 11, No. 7. pp. 1593-1596.
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