TY - JOUR
T1 - DNA damaging activity of ellagic acid derivatives
AU - Xu, Ya Ming
AU - Deng, Jing Zhen
AU - Ma, Ji
AU - Chen, Shao Nong
AU - Marshall, Rebekah
AU - Jones, Shannon H.
AU - Johnson, Randall K.
AU - Hecht, Sidney M.
N1 - Funding Information:
We thank Dr. John Beisler, National Cancer Institute, for a helpful discussion during the course of this work. This work was supported by NIH research grant CA50771 from the National Cancer Institute.
PY - 2003/4
Y1 - 2003/4
N2 - A strain of yeast rendered repair deficient by the conditional expression of the RAD52 locus was used to search for natural products capable of damaging DNA. Four ellagic acid derivatives, namely 3,3′-dimethyl-4′-O-β-D-glucopyranosyl ellagic acid (1), 3,3′,4-trimethyl-4′-O-β-D-glucopyranosyl ellagic acid (2), 3′-methyl-3,4-O,O-methylidene ellagic acid (3) and 3′-methyl-3,4-O,O-methylidene-4′-O-β-D-glucopyranosyl ellagic acid (4), were identified by this assay as DNA damaging natural principles from several plants, including Alangium javanicum, Anisophyllea apetala, Crypteronia paniculata, Mouririi sp. and Scholtzia parviflora. Although none of the isolated principles mediated frank strand scission of DNA in vitro, all of them potently inhibited the growth of yeast in the absence of expression of RAD52.
AB - A strain of yeast rendered repair deficient by the conditional expression of the RAD52 locus was used to search for natural products capable of damaging DNA. Four ellagic acid derivatives, namely 3,3′-dimethyl-4′-O-β-D-glucopyranosyl ellagic acid (1), 3,3′,4-trimethyl-4′-O-β-D-glucopyranosyl ellagic acid (2), 3′-methyl-3,4-O,O-methylidene ellagic acid (3) and 3′-methyl-3,4-O,O-methylidene-4′-O-β-D-glucopyranosyl ellagic acid (4), were identified by this assay as DNA damaging natural principles from several plants, including Alangium javanicum, Anisophyllea apetala, Crypteronia paniculata, Mouririi sp. and Scholtzia parviflora. Although none of the isolated principles mediated frank strand scission of DNA in vitro, all of them potently inhibited the growth of yeast in the absence of expression of RAD52.
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U2 - 10.1016/S0968-0896(02)00452-2
DO - 10.1016/S0968-0896(02)00452-2
M3 - Article
C2 - 12628683
AN - SCOPUS:0037375454
SN - 0968-0896
VL - 11
SP - 1593
EP - 1596
JO - Bioorganic and Medicinal Chemistry
JF - Bioorganic and Medicinal Chemistry
IS - 7
ER -