DNA-based materials as self-assembling scaffolds for interfacing with cells

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

In this chapter, we will outline key applications for DNA as a scaffold for interfacing with and guiding the activity of biological systems. DNA is a highly programmable molecular building block but generally lacks activity for signaling cells. However, by synthesizing hybrid molecules of DNA linked to biologically active molecules like proteins or peptides, it is possible to imbue them with bioactivity. We will focus on two main categories of DNA-based materials: (1) three-dimensional hydrogels for cell encapsulation and/or delivery and (2) two-dimensional surfaces for studying cell-matrix interactions. Critically, we will restrict ourselves to systems that incorporate cells and strive to mimic the extracellular environment. These materials are highly promising for a broad range of applications in biology, bioengineering, and medicine.

Original languageEnglish (US)
Title of host publicationSelf-Assembling Biomaterials
Subtitle of host publicationMolecular Design, Characterization and Application in Biology and Medicine
PublisherElsevier
Pages157-175
Number of pages19
ISBN (Electronic)9780081020159
ISBN (Print)9780081020128
DOIs
StatePublished - Jan 1 2018

Keywords

  • DNA nanotechnology
  • Dynamic biomaterials
  • Regenerative medicine
  • Self-assembly
  • Stem-cell biology

ASJC Scopus subject areas

  • Engineering(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Stephanopoulos, N., & Freeman, R. (2018). DNA-based materials as self-assembling scaffolds for interfacing with cells. In Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine (pp. 157-175). Elsevier. https://doi.org/10.1016/B978-0-08-102015-9.00008-3