DNA and RNA in anhydrous media: Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent

Irena Mamajanov, Aaron E. Engelhart, Heather D. Bean, Nicholas V. Hud

Research output: Contribution to journalArticle

119 Scopus citations

Abstract

Hold the water! Deep-eutectic solvents (DESs) are nonvolatile media suitable for a wide range of chemical reactions. The discovery that nucleic acids can form duplex, triplex, and G quadruplex structures (which in some cases differ from those adopted in aqueous media) in a water-free DES (see picture) opens the enticing possibility that catalytic nucleic acids and enzyme-nucleic acid complexes could also be used in these solvents.

Original languageEnglish (US)
Pages (from-to)6310-6314
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number36
DOIs
StatePublished - Aug 23 2010
Externally publishedYes

Keywords

  • DNA structures
  • Ionic liquids
  • Nucleic acids
  • Solvent effects
  • Sustainable chemistry

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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