DNA and RNA in anhydrous media

Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent

Irena Mamajanov, Aaron E. Engelhart, Heather Bean, Nicholas V. Hud

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

Hold the water! Deep-eutectic solvents (DESs) are nonvolatile media suitable for a wide range of chemical reactions. The discovery that nucleic acids can form duplex, triplex, and G quadruplex structures (which in some cases differ from those adopted in aqueous media) in a water-free DES (see picture) opens the enticing possibility that catalytic nucleic acids and enzyme-nucleic acid complexes could also be used in these solvents.

Original languageEnglish (US)
Pages (from-to)6310-6314
Number of pages5
JournalAngewandte Chemie - International Edition
Volume49
Issue number36
DOIs
StatePublished - Aug 23 2010
Externally publishedYes

Fingerprint

Nucleic acids
RNA
Eutectics
Nucleic Acids
DNA
Water
Chemical reactions
Enzymes

Keywords

  • DNA structures
  • Ionic liquids
  • Nucleic acids
  • Solvent effects
  • Sustainable chemistry

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis

Cite this

DNA and RNA in anhydrous media : Duplex, triplex, and G-quadruplex secondary structures in a deep eutectic solvent. / Mamajanov, Irena; Engelhart, Aaron E.; Bean, Heather; Hud, Nicholas V.

In: Angewandte Chemie - International Edition, Vol. 49, No. 36, 23.08.2010, p. 6310-6314.

Research output: Contribution to journalArticle

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