Diversity considerations in HIV-1 vaccine selection

Brian Gaschen, Jesse Taylor, Karina Yusim, Brian Foley, Feng Gao, Dorothy Lang, Vladimir Novitsky, Barton Haynes, Beatrice H. Hahn, Tanmoy Bhattacharya, Bette Korber

Research output: Contribution to journalArticle

609 Citations (Scopus)

Abstract

Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of their amino acids. To contend with the diversity, country-specific vaccines are being considered, but evolutionary relationships may be more useful than regional considerations. Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.

Original languageEnglish (US)
Pages (from-to)2354-2360
Number of pages7
JournalScience
Volume296
Issue number5577
DOIs
StatePublished - Jun 28 2002
Externally publishedYes

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HIV-1
Vaccines
Human Immunodeficiency Virus env Gene Products
AIDS Vaccines
Viruses
Amino Acids

ASJC Scopus subject areas

  • General

Cite this

Gaschen, B., Taylor, J., Yusim, K., Foley, B., Gao, F., Lang, D., ... Korber, B. (2002). Diversity considerations in HIV-1 vaccine selection. Science, 296(5577), 2354-2360. https://doi.org/10.1126/science.1070441

Diversity considerations in HIV-1 vaccine selection. / Gaschen, Brian; Taylor, Jesse; Yusim, Karina; Foley, Brian; Gao, Feng; Lang, Dorothy; Novitsky, Vladimir; Haynes, Barton; Hahn, Beatrice H.; Bhattacharya, Tanmoy; Korber, Bette.

In: Science, Vol. 296, No. 5577, 28.06.2002, p. 2354-2360.

Research output: Contribution to journalArticle

Gaschen, B, Taylor, J, Yusim, K, Foley, B, Gao, F, Lang, D, Novitsky, V, Haynes, B, Hahn, BH, Bhattacharya, T & Korber, B 2002, 'Diversity considerations in HIV-1 vaccine selection', Science, vol. 296, no. 5577, pp. 2354-2360. https://doi.org/10.1126/science.1070441
Gaschen B, Taylor J, Yusim K, Foley B, Gao F, Lang D et al. Diversity considerations in HIV-1 vaccine selection. Science. 2002 Jun 28;296(5577):2354-2360. https://doi.org/10.1126/science.1070441
Gaschen, Brian ; Taylor, Jesse ; Yusim, Karina ; Foley, Brian ; Gao, Feng ; Lang, Dorothy ; Novitsky, Vladimir ; Haynes, Barton ; Hahn, Beatrice H. ; Bhattacharya, Tanmoy ; Korber, Bette. / Diversity considerations in HIV-1 vaccine selection. In: Science. 2002 ; Vol. 296, No. 5577. pp. 2354-2360.
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