Diversity considerations in HIV-1 vaccine selection

Brian Gaschen, Jesse Taylor, Karina Yusim, Brian Foley, Feng Gao, Dorothy Lang, Vladimir Novitsky, Barton Haynes, Beatrice H. Hahn, Tanmoy Bhattacharya, Bette Korber

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611 Scopus citations

Abstract

Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ in more than 30% of their amino acids. To contend with the diversity, country-specific vaccines are being considered, but evolutionary relationships may be more useful than regional considerations. Consensus or ancestor sequences could be used in vaccine design to minimize the genetic differences between vaccine strains and contemporary isolates, effectively reducing the extent of diversity by half.

Original languageEnglish (US)
Pages (from-to)2354-2360
Number of pages7
JournalScience
Volume296
Issue number5577
DOIs
StatePublished - Jun 28 2002

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Cite this

Gaschen, B., Taylor, J., Yusim, K., Foley, B., Gao, F., Lang, D., Novitsky, V., Haynes, B., Hahn, B. H., Bhattacharya, T., & Korber, B. (2002). Diversity considerations in HIV-1 vaccine selection. Science, 296(5577), 2354-2360. https://doi.org/10.1126/science.1070441