Diverse papillomaviruses identified in weddell seals

Zoe E. Smeele, Jennifer M. Burns, Koenraad Van Doorsaler, Rafaela S. Fontenele, Kara Waits, Daisy Stainton, Michelle R. Shero, Roxanne S. Beltran, Amy L. Kirkham, Rachel Berngartt, Simona Kraberger, Arvind Varsani

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Papillomaviridae is a diverse family of circular, double-stranded DNA (dsDNA) viruses that infect a broad range of mammalian, avian and fish hosts. While papillomaviruses have been characterized most extensively in humans, the study of non-human papillomaviruses has contributed greatly to our understanding of their pathogenicity and evolution. Using high-throughput sequencing approaches, we identified 7 novel papillomaviruses from vaginal swabs collected from 81 adult female Weddell seals (Leptonychotes weddellii) in the Ross Sea of Antarctica between 2014–2017. These seven papillomavirus genomes were amplified from seven individual seals, and six of the seven genomes represented novel species with distinct evolutionary lineages. This highlights the diversity of papillomaviruses among the relatively small number of Weddell seal samples tested. Viruses associated with large vertebrates are poorly studied in Antarctica, and this study adds information about papillomaviruses associated with Weddell seals and contributes to our understanding of the evolutionary history of papillomaviruses.

Original languageEnglish (US)
Pages (from-to)549-557
Number of pages9
JournalJournal of General Virology
Volume99
Issue number4
DOIs
StatePublished - Apr 2018

Keywords

  • Antarctic
  • Carnivora
  • Leptonychotes weddellii
  • Papillomavirus

ASJC Scopus subject areas

  • Virology

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    Smeele, Z. E., Burns, J. M., Van Doorsaler, K., Fontenele, R. S., Waits, K., Stainton, D., Shero, M. R., Beltran, R. S., Kirkham, A. L., Berngartt, R., Kraberger, S., & Varsani, A. (2018). Diverse papillomaviruses identified in weddell seals. Journal of General Virology, 99(4), 549-557. https://doi.org/10.1099/jgv.0.001028