Divergence of biological and chronological aging: Evidence from rodent studies

Timothy J. Collier, Paul D. Coleman

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

Literature on aging populations of rodents supports the intuitive view that significant functional variation exists among like-aged, elderly individuals: chronological age as a solitary measure is a poor indicator of biological age. In this report, we review a variety of studies which classify aged rodents based on genetic and/or behavioral similarities, in addition to chronological age, and have provided valuable neurobiological and physiological information on age-related changes which accompany functional impairments, or the lack of them. Beyond their descriptive value for gerontological research, these findings suggest ways in which biological aging can be manipulated to promote good function in aged individuals.

Original languageEnglish (US)
Pages (from-to)685-693
Number of pages9
JournalNeurobiology of Aging
Volume12
Issue number6
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

Keywords

  • Acetyl-L-carnitine
  • Aging
  • Centrophenoxine
  • Cognitive behavior
  • Food restriction
  • Genetics
  • Handling
  • Learning
  • Memory
  • Motor behavior
  • Neophobia
  • Rodents

ASJC Scopus subject areas

  • Neuroscience(all)
  • Aging
  • Clinical Neurology
  • Developmental Biology
  • Geriatrics and Gerontology

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