Divergence of biological and chronological aging: Evidence from rodent studies

Timothy J. Collier; Paul D. Coleman

doi:10.1016/0197-4580(91)90122-Z

Divergence of biological and chronological aging: Evidence from rodent studies

Timothy J. Collier, Paul D. Coleman

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Literature on aging populations of rodents supports the intuitive view that significant functional variation exists among like-aged, elderly individuals: chronological age as a solitary measure is a poor indicator of biological age. In this report, we review a variety of studies which classify aged rodents based on genetic and/or behavioral similarities, in addition to chronological age, and have provided valuable neurobiological and physiological information on age-related changes which accompany functional impairments, or the lack of them. Beyond their descriptive value for gerontological research, these findings suggest ways in which biological aging can be manipulated to promote good function in aged individuals.

Original language	English (US)
Pages (from-to)	685-693
Number of pages	9
Journal	Neurobiology of Aging
Volume	12
Issue number	6
DOIs	https://doi.org/10.1016/0197-4580(91)90122-Z
State	Published - 1991
Externally published	Yes

Keywords

Acetyl-L-carnitine
Aging
Centrophenoxine
Cognitive behavior
Food restriction
Genetics
Handling
Learning
Memory
Motor behavior
Neophobia
Rodents

ASJC Scopus subject areas

Neuroscience(all)
Aging
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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10.1016/0197-4580(91)90122-Z

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abstract = "Literature on aging populations of rodents supports the intuitive view that significant functional variation exists among like-aged, elderly individuals: chronological age as a solitary measure is a poor indicator of biological age. In this report, we review a variety of studies which classify aged rodents based on genetic and/or behavioral similarities, in addition to chronological age, and have provided valuable neurobiological and physiological information on age-related changes which accompany functional impairments, or the lack of them. Beyond their descriptive value for gerontological research, these findings suggest ways in which biological aging can be manipulated to promote good function in aged individuals.",

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T1 - Divergence of biological and chronological aging

T2 - Evidence from rodent studies

AU - Collier, Timothy J.

AU - Coleman, Paul D.

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AB - Literature on aging populations of rodents supports the intuitive view that significant functional variation exists among like-aged, elderly individuals: chronological age as a solitary measure is a poor indicator of biological age. In this report, we review a variety of studies which classify aged rodents based on genetic and/or behavioral similarities, in addition to chronological age, and have provided valuable neurobiological and physiological information on age-related changes which accompany functional impairments, or the lack of them. Beyond their descriptive value for gerontological research, these findings suggest ways in which biological aging can be manipulated to promote good function in aged individuals.

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KW - Food restriction

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KW - Handling

KW - Learning

KW - Memory

KW - Motor behavior

KW - Neophobia

KW - Rodents

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Divergence of biological and chronological aging: Evidence from rodent studies

Abstract

Keywords

ASJC Scopus subject areas

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