Abstract

Biological membranes are one of the important interfaces between cells and pollutants. Many polar and hydrophobic chemicals can accumulate within these membranes. For this reason, artificial biological membranes are appealing surrogates to complex organisms for assessing the bioaccumulation potential of engineered nanomaterials (ENMs). To our knowledge, this work presents the first quantitative study on the distribution of fullerene ENMs between lipid bilayers, used as model biological membranes, and water. We evaluated the lipid bilayer-water association coefficients (K lipw) of aqueous fullerene aggregates (nC 60) and fullerol (C 60(ONa) x(OH) y, x + y = 24). Kinetic studies indicated that fullerol reached apparent equilibrium more rapidly than nC 60 (2 h versus >9 h). Nonlinear isotherms can describe the distribution behavior of nC 60 and fullerol. The lipid bilayer-water distributions of both nC 60 and fullerol were pH-dependent with the accumulation in lipid bilayers increasing systematically as the pH decreased from 8.6 (natural water pH) to 3 (the low end of physiologically relevant pH). This pH dependency varies with the zeta potentials of the ENMs and leads to patterns similar to those previously observed for the lipid bilayer-water distribution behavior of ionizable organic pollutants. The K lipw value for nC 60 was larger than that of fullerol at a given pH, indicating a greater propensity for nC 60 to interact with lipid bilayers. For example, at pH 7.4 and an aqueous concentration of 10 mg/L, K lipw was 3.5 times greater for nC 60 (log K lipw = 2.99) relative to fullerol (log K lipw = 2.45). Comparisons with existing aquatic organism bioaccumulation studies suggested that the lipid bilayer-water distribution is a potential method for assessing the bioaccumulation potentials of ENMs.

Original languageEnglish (US)
Pages (from-to)11899-11905
Number of pages7
JournalLangmuir
Volume27
Issue number19
DOIs
StatePublished - Oct 4 2011

Fingerprint

Fullerenes
Biological membranes
bionics
Lipid bilayers
Nanostructured materials
fullerenes
lipids
membranes
Water
Bioaccumulation
water
organisms
contaminants
Aquatic organisms
Organic pollutants
Zeta potential
Isotherms
isotherms
Association reactions
Membranes

ASJC Scopus subject areas

  • Electrochemistry
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Materials Science(all)
  • Spectroscopy

Cite this

Distribution of fullerene nanomaterials between water and model biological membranes. / Hou, Wen Che; Moghadam, Babak Yaghoubi; Westerhoff, Paul; Posner, Jonathan D.

In: Langmuir, Vol. 27, No. 19, 04.10.2011, p. 11899-11905.

Research output: Contribution to journalArticle

Hou, Wen Che ; Moghadam, Babak Yaghoubi ; Westerhoff, Paul ; Posner, Jonathan D. / Distribution of fullerene nanomaterials between water and model biological membranes. In: Langmuir. 2011 ; Vol. 27, No. 19. pp. 11899-11905.
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